水滑石负载手性席夫碱催化酮不对称硅氢加成  

Asymmetric Hydrosilylation of Prochiral Ketone Catalyzed with Schiff Base Supported on Hydrotalcite

作　　者：王磊[1] 彭家建[1] 白赢[1] 厉嘉云[1] 肖文军[1] 陈峰[1] 来国桥[1] 

机构地区：[1]杭州师范大学有机硅化学及材料技术教育部重点实验室,浙江杭州311121

出　　处：《杭州师范大学学报（自然科学版）》2013年第6期481-485,共5页Journal of Hangzhou Normal University(Natural Science Edition)

基　　金：国家自然科学基金青年科学基金项目(21203049)

摘　　要：以水滑石为载体,负载一系列手性α-氨基酸席夫碱来催化潜手性酮硅氢加成反应,继而水解得到手性二级醇.结果表明,在催化苯乙酮和三乙氧基硅烷的硅氢加成反应中,转化率达95%以上,ee值达57%.The exploration for economical and effective synthesis methods of chiral alcohols is a rewarding research, owing to the numerous applications in the fields of pharmaceuticals, flavors, cosmetics and agrochemicals. Using a new method with a series of chiral α-amino acid schiff base supported on hydrotalcite as catalyst to catalyze the prochiral ketones hydrosilylation reaction, chiral secondary alcohols were obtained after the hydrolysis. The results indicate that the conversation rate is above 95 % and ee value is up to 57 % in the hydrosilylation of catalyzing acetophenone and triethoxysilane.

关 键 词：不对称催化硅氢加成 潜手性酮 α-氨基酸席夫碱 水滑石 

分 类 号：TQ426.6[化学工程]