11C-PIBPET在不同时期阿尔茨海默病中的研究进展  

Application of 11C-PIB PET in different period of the Alzheimer disease

作　　者：王颖[1] 蔡莉[1] 李彦生[1] 高硕[1] 

机构地区：[1]天津医科大学总医院PET/CT中心,300052

出　　处：《国际放射医学核医学杂志》2013年第6期378-380,384,共4页International Journal of Radiation Medicine and Nuclear Medicine

摘　　要：阿尔茨海默病（AD）作为神经变性病，起病隐袭，早期诊断困难。β淀粉样蛋白（Aβ）沉积形成的老年斑是其特征性病理改变，并且发生在疾病的早期阶段。N-[11C]甲基-2—4＇-甲基氨基苯基-6-羟基苯并噻唑（11C-PIB）作为Aβ特异性的分子探针，能够无创、实时、定量地监测脑内纤维状Aβ的变化。因此，明确PIB在不同时期AD中的分布特点，对AD的早期诊断、抗Aβ治疗的人群筛选以及疗效监测方面都具有重要意义。该文就近年来11C-PIBPET在不同时期AD中的应用作一综述。Alzheimer disease （AD） is a neurodegenerative disease, h is difficult to make an early diagnosis because it is insidious onset. One of the neuropathological hallmarks of AD is the formation of senile plaques, which is composed of fibril amyloid 13-protein （Aβ）. And amyloid deposition is an early event on the path to dementia. N-[11C] methyl-2-4＇-methylaminophenyl-6-hydroxybenzothiazole （11C-PIB） is a specific molecular probe of AI3, which could monitor the change of fibril Aβ non-invasively, dynamically and quantitatively. In order to aid early diagnosis, screen the population for antiamyloid therapies and monitor the therapeutic effects, it is urgent to elucidate the PIB characteristics of distribution at different stage of AD. Therefore, the application of 11C-PIB PET in AD in the latest years will be summarized.

关 键 词：阿尔茨海默病 淀粉样Β蛋白 正电子发射断层显像术 

分 类 号：R817.4[医药卫生—影像医学与核医学] R749.16[医药卫生—放射医学]