幽门螺杆菌感染与冠心病发病关系探讨  

PRELIMINARY EXPLORATION OF THE ASSOCIATION BETWEEN HELIC OBACTER PYLORI INFECTION AND CORONARY HEART DISEASE

作　　者：曾智[1] 黄明惠[1] 梁玉佳[1] 张庆[1] 蒋涛[2] 刘运贵[2] 李健[2] 

机构地区：[1]华西医科大学附属第一医院,成都610044 [2]四川省绵阳市中心医院

出　　处：《中国现代医学杂志》2000年第10期27-28,共2页China Journal of Modern Medicine

摘　　要：目的 :探讨幽门螺杆菌 (Hp)感染与冠心病 (CHD)发病的关系及产细胞毒素Hp菌株对CHD的影响。方法 :采用成组病例对照研究。两组病例均采用间接酶标法 (ELISA)检测血清Hp特异性抗体IgG及产细胞毒素HpIgG。结果 :HpIgG阳性率及HpIgG平均浓度病例组与对照组比较有显著性差异 ;HpIgG阳性与CHD有相关关系 ,且在校正年龄因素后仍有相关关系。产细胞毒素HpIgG阳性率两组比较无显著性差异 ,且它与CHD无相关关系。CHD组中检测抗HpIgG阳性与阴性血脂和WBC计数均无显著性差异。结论 :Hp感染可能是CHD发病的一个重要危险因素 ,但尚需前瞻性研究证实。Objective: To explore the association between Hp infection and CHD and to determine the effects of cytotoxic strains of Hp on CHD. Methods: A nested case-control study. Cases are angiographically documented CHD patients and diagnosed acute myocardial infarction patients. Controls are patients without history of CDH matched for age, gender and occupation. Serum was analyzed for the presence of Hp specific IgG antibodies and cytotoxic strains of Hp specific IgG antibodies by ELISA. Results: The proportion of Hp-positive individuals and the average concentration of Hp IgG were higher in the cases than the controls. The Hp seropositivity was related to CHD (OR=1.0389, P =0.018); The association was not altered after adjustment for age by multiple logistic regression (OR=1.040, P =0.019). No increase was found in cytotoxic strains of Hp seropositivity in cases compared with controls and the association was not found between cytotoxic stains of Hp seronegativity among cases about CHO, TG, HDL, WBC. Conclusions: Hp infection may be an important risk factor for CHD. But it needs to be confirmed by more prospective studies.

关 键 词：幽门螺杆菌感染 冠心病 病理 危险因素 

分 类 号：R541.402[医药卫生—心血管疾病]