聚六亚甲基双胍盐酸盐的杀菌活性及现场空气消毒效果观察  

EXPERIMENTAL OBSERVATION ON BACTERICIDAL ACTIVITY AND FIELD DISINFECTION EFFICACY OF INDOOR AIR BY POLYHEXAMETHYLENE BIGUANIDINE HYDROCHLORIDE

作　　者：张先菊[1] 苏裕心[2] 任哲[2] 魏秋华[2] 宋世佩 陈晨[3] 邓致荣[3] 张文福[2] 

机构地区：[1]武警总医院,北京100039 [2]军事医学科学院疾病预防控制所 [3]第二炮兵防疫队

出　　处：《中国消毒学杂志》2013年第11期1016-1018,1021,共4页Chinese Journal of Disinfection

基　　金：总后勤部卫生部应用基础研究项目(CWS11J202)

摘　　要：目的观察聚六亚甲基双胍盐酸盐的杀菌活性和现场空气消毒效果。方法采用悬液定量杀菌试验和空气消毒现场试验方法,对盐酸聚六亚甲基双胍杀菌效果和现场空气消毒效果进行了观察。结果用浓度为128mg/L盐酸聚六亚甲基双胍消毒液对悬液内金黄色葡萄球菌作用3.0 min,杀灭对数值>5.0;用256 mg/L的该消毒液对悬液内大肠杆菌作用4.5 min,杀灭对数值>5.0;用1 024 mg/L的该消毒液对悬液内白色念珠菌作用6.0 min,杀灭对数值>4.0。用浓度为2 000 mg/L的该消毒液以10 ml/m3用量进行气溶胶喷雾密闭作用30 min,对室内空气中自然菌的消除率>90%。结论该盐酸聚六亚甲基双胍对细菌繁殖体和真菌都有较好的杀灭效果,对空气中自然菌也能达到很好的消毒效果。Objective To explore the germicidal properties and indoor air decontamination efficacy of polyhexamethylene biguanidine hydroehloride（ PHMB ·HC1）. Methods Suspension quantitative germicidal test and air field air disinfection test were used to evaluate the bactericidal activity and field disinfection effect of the PHMB HC1. Results The average killing logarithm values of Staphylococcus aureus in suspension exposed to 128 mg/L PHMB HC1 solution for 3.0 rain was 〉 5.0. And which of Escherichia coli exposed to 256 mg/L PHMB· HC1 solution for 4. 5 rain was 〉 5.0, while that of Candida albicans exposed to 1 024 mg/L PHMB ·HC1 solution for 6. 0 min was 〉 4. 0. It was observed in experiment that aerosol spray of 2 000 mg/L PHMB· HC1 solution at a dosage of 10 ml/m3 for 30 min in a closed room eliminated over 90% of natural bacteria in air. Conclusions The PHMB HC1 can kill vegetative forms of bacteria and Candida albicans effectively, and can effectively eliminate over 90% of natural bacteria in indoor air with aerosol spray of 2 000 mg/L PHMB HC1 solution.

关 键 词：聚六亚甲基双胍盐酸盐 消毒剂 杀菌效果 空气消毒 

分 类 号：R187.2[医药卫生—流行病学]