49例肿瘤患者感染血培养阳性菌谱分析  

ANALYSIS OF POSITIVE BACTERIAL BLOOD CULTURE OF 49 TUMOR PATIENTS

作　　者：林莉[1] 王岩[1] 葛飞娇[1] 翟红岩[1] 赵传华[1] 付亚莉[1] 王淼[1] 徐建明[1] 

机构地区：[1]中国人民解放军三0七医院,北京100071

出　　处：《中国消毒学杂志》2013年第11期1042-1044,共3页Chinese Journal of Disinfection

基　　金：中华医院感染控制研究基金资助

摘　　要：目的了解住院肿瘤患者感染血标本培养阳性病原菌分布及易感因素,为预防血流感染和合理使用抗生素提供依据。方法采用回顾性调查法,某医院消化肿瘤科49例感染患者血液标本病原学检测结果进行了调查与分析。结果从49例血液标本中分离出病原菌70株,包括革兰阴性菌40株,占57.14%;革兰阳性菌25株,占35.71%;真菌5株,占7.14%。来自单纯血流感染患者标本23份,占46.94%;其余26例分别从痰液、尿液等标本中检出同源感染菌。革兰阴性和阳性优势菌大肠埃希菌和表皮葡萄球菌对多数抗菌药物耐药,但均对万古霉素和亚胺培南敏感。结论住院肿瘤患者血培养阳性中仅46.94%为血流感染,主要为革兰阴性杆菌,其优势菌普遍耐药。Objective To investigate blood culture positive pathogens distribution and predisposing factors from tumor patients in hospital and to provide the guidance for the prevention of bloodstream infection and rational drug use in clinic. Methods Retrospective investigation was used to investigate and analyze pathogens of the positive blood culture from 49 cases. Results 70 strains of pathogenic bacteria were isolated from blood culture samples of 49 patients, including 40 strains of Gram - negative bacteria （57.14%）, 25 Gram - positive strains （35.71%）, 5 strains of fungi （7.14%）. 23 cases were pure bloodstream infection which accounting for 46. 94%, homologous infection bacteria were detected from spu- tum or urine specimens from the remaining 26 cases. Gram - negative and Gram - positive bacteria were Escherichia coli and Staphylococcus which resistant to most antibiotics and sensitive to vaneomycin and imipenem. Conclusion Patients with bloodstream infection accounted for only 46.94% among those with positive blood culture in hospital, the main patho- gens were gram - positive bacteria which had general drug resistance.

关 键 词：肿瘤患者 血流感染 革兰阴性菌 耐药性 

分 类 号：R378[医药卫生—病原生物学]