高正加速度应激对人体唾液睾酮及皮质醇的影响  

Effect of +Gz stress on testosterone and cortisol levels in human saliva

作　　者：薛霞[1] 薛红[2] 李卫东[2] 王旭芳[2] 

机构地区：[1]空军航空医学研究所附属医院空勤科,北京100089 [2]空军航空医学研究所附属医院检验科,北京100089

出　　处：《解放军医学院学报》2013年第11期1189-1191,共3页Academic Journal of Chinese PLA Medical School

摘　　要：目的探讨高正加速度(+Gzz)应激对飞行员唾液睾酮(testosterone,T)、皮质醇(cortisol,C)及二者比值(T/C)的影响。方法 47例高性能战斗机飞行员为研究对象,分别在+6.5 Gz,+7.0 Gz和+8.0 Gz暴露前后取受试者唾液,采用微粒子化学发光法检测唾液T及C水平。结果 +6.5 Gz、+7.0 Gz、+8.0 Gz作用后唾液T浓度与暴露前相比无统计学差异;唾液C的浓度均高于+Gz暴露前水平(P<0.05),其中+8.0 Gz暴露后C较+6.5 Gz后、+7.0 Gz前、+8.0 Gz前均高(P<0.05);T/C值在不同+Gz暴露后呈现出不同的变化趋势,但并没有统计学差异。多元方差分析结果显示机种、年龄、飞行总时间对不同+Gz暴露后飞行员唾液T、C以及T/C变化无影响。唾液T与C在高+Gz应激后的变化无相关性;年龄与基础T/C呈正相关性。结论 +Gz暴露时提高了飞行员的唾液C浓度,提示唾液可能作为飞行员应激及疲劳的评价指标。Objective To study the effect of ＋Gz stress on testosterone （T） and cortisol （C） levels and T/C in saliva of pilots. Methods Forty-seven pilots of high performance fighter were included in this study. Saliva samples were taken before and after they were exposed to ＋6.5 Gz, ＋7.0 Gz and ＋8.0 Gz. T and C levels in saliva were measured by chemiluminescent immunoassay. Results Nosignificant difference was found in the T level in saliva of the pilots before and after exposure to ＋6.5 Gz, ＋7.0 Gz and ＋8.0 Gz. The C level was significantly higher in saliva of the pilots after exposure to ＋6.5 Gz, ＋7.0 Gz and ＋8,0 Gz than before exposure to them （P 〈 0.05） and after exposure to ＋8.0 Gz than before exposure to ＋6.5 Gz, ＋7.0 Gz and ＋8.0 Gz （P 〈 0.05）. No significant difference was found in the T/C in saliva of the pilots after exposure to different ＋Gz stresses although it tended to change. ANOVA analysis showed that the type of fighter, the age and total flight time of pilots had no effect on the T and C levels and T/C after exposure to different ＋Gz stresses. The T level was not related with the C level in saliva of pilots after exposure to different ＋Gz stresses. Age was positively related with baseline T/C. Conclusion The elevated C level in saliva of pilots after exposure to ＋Gz indicates that saliva can be used as an indicator of stress and fatigue in pilots.

关 键 词：加速度 睾酮 皮质醇 睾酮 皮质醇 

分 类 号：R854[医药卫生—航空、航天与航海医学]