进行性血红蛋白减少-继发性纯红细胞再生障碍性贫血1例报告  

Secondary pure red cell aplasia due to progressive hemoglobin reduction: A case report

作　　者：杨光[1] 程庆砾[1] 张冬梅[1] 敖强国[1] 张晓英[1] 刘胜[1] 

机构地区：[1]解放军总医院南楼肾脏病科,北京100853

出　　处：《解放军医学院学报》2013年第11期1192-1194,共3页Academic Journal of Chinese PLA Medical School

摘　　要：目的提高对药物引起的纯红细胞再生障碍性贫血(pure red cell aplasia,PRCA)的认识水平。方法报告并分析1例异烟肼引起的纯红细胞再生障碍性贫血的疾病特征及诊治经过。患者为94岁的高龄老年人,该患者主要诊断为肺结核和慢性肾脏病,在治疗过程中出现进行性贫血,通过骨髓活检诊断为PRCA,起初误诊为抗促红细胞生成素(erythropoietin,EPO)抗体引起的PRCA。结果最后找到的真正原因为异烟肼引起的PRCA。结论本例患者为我们提供了临床实证,应用抗结核药物治疗过程中出现无法解释的贫血,可能为异烟肼引起的PRCA。Objective To improve the understanding of drug-induced pure red cell aplasia（PRCA）. Methods A case of isoniazid- induced PRCA was reported. The features, diagnosis and treatment of isoniazid-induced PRCA were analyzed. The case was a 94 years old man who was diagnosed with pulmonary tuberculosis （TB） and chronic kidney disease（CKD）. Progressive anemia occurred during his treatment was finally diagnosed as PRCA by bone marrow biopsy, which was initially misdiagnosed as anti-EPO antibody- induced PRCA. Results Finally we found that PRCA was induced by isoniazid. Conclusion This case provides the clinical evidence for unexplained anemia occurred during the drug therapy for TB and isoniazid may induce PRCA.

关 键 词：老年人 异烟肼 纯红细胞再生障碍性贫血 

分 类 号：R556.5[医药卫生—血液循环系统疾病]