复方环孢菌素A漱口液的研制与临床应用  

Clinical Application and Preparation of Compound Cyclosprine Gargle

作　　者：柳志文[1] 凌天牖[1] 贺建泽[1] 吴汉江[1] 李运良[1] 程泽能[1] 叶建新 

机构地区：[1]湖南医科大学附属第二医院,长沙市410011 [2]华东制药厂

出　　处：《中国药房》2000年第6期257-258,共2页China Pharmacy

基　　金：本课题为湖南省卫生厅基金项目;编号:9643

摘　　要：目的：设计一种治疗口腔免疫损伤和厌氧菌感染制剂的处方和制备工艺，建立制剂的含量测定方法，并进行其初步临床应用。方法：参照类似产品设计处方，高效液相色谱法测定含量，选择口腔扁平苔藓患者进行临床观察。结果：本品口感较好，质量可控，临床治疗口腔扁平苔藓有效率为９６％，无明显副作用。结论：制剂口感较好，含量测定方法可靠，临床疗效较好。OBJECTIVE: A gargle was designed and prepared for treating immune inpairment and anaerobic infection of oral cavity .The method of its quantitative analysis was established and put into clinical use. METHODS: HPLC was used as the quantitative analysis method .The effect on oral lichen planus was clinically observed. RESULTS: The taste of the gargle was well acceptable, and its quality was well controlled.The cure rate for oral lichen planus was 96%. No adverse reactions were found. CONCLUSION: The taste and method of quantitative analysis are well acceptable. The clinical effect is satisfactory.

关 键 词：环孢菌素A 替硝唑 漱口液制备 临床应用 

分 类 号：R978.11[医药卫生—药品] R988.2[医药卫生—药学]