正交试验优化芩双颗粒喷雾制粒工艺  

Orthogonal Test for Optimization of Qinshuang Particle Spray Granulation Process

作　　者：姜鸿[1] 王光函[1] 吴怡[1] 尤献民[1] 吕晓东[2] 

机构地区：[1]辽宁省中医药研究院,沈阳110034 [2]辽宁中医药大学第一附属医院,沈阳110032

出　　处：《世界科学技术-中医药现代化》2013年第6期1437-1440,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家科技重大专项(2010ZX09401-304):辽宁省国家创新药物孵化基地建设项目--芩双颗粒新药开发研究;负责人:吕晓东

摘　　要：目的：优化芩双颗粒的最佳喷雾制粒工艺条件。方法：采用正交试验法,以颗粒成品率和黄芩苷转移率为考察指标,对芩双颗粒喷雾制粒过程的主要影响因素进行考察。结果：最佳工艺参数为雾化压力1 800 Pa,进口温度90℃~100℃,出口温度50℃~60℃,流浸膏相对密度1.10（60℃测定）。结论：该工艺条件合理,制得颗粒质量稳定,为工业化生产提供依据。This study was aimed to optimize Qinshuang particle best spray granulation process conditions. The or-thogonal test method was used with grain yield and baicalin transfer rate as the inspection indexes. The main in-fluence factors of Qinshuang particle spray granulation process were investigated. The results showed that the best technological parameters are atomization pressure of 1 800 Pa, inlet temperature at 90°C - 100°C, outlet temper-ature at 50 ° C - 60 ° C , and the extract relative density of 1 . 10 （ 60 ° C ） . It was concluded that the reasonable pro-cess conditions make particles with stable quality, which provide the experimental basis for industrial production.

关 键 词：芩双颗粒 喷雾制粒 正交试验 黄芩苷 

分 类 号：R283.6[医药卫生—中药学]