小儿久咳方对小儿久咳炎症免疫的调节作用及疗效观察  

Immune Regulation and Therapeutic Observation of Anti-Cough in Children Treated with Pediatric Long-term Cough Decoction

作　　者：马俊杰[1] 周春祥[1] 

机构地区：[1]南京中医药大学基础医学院,南京210046

出　　处：《世界科学技术-中医药现代化》2013年第7期1600-1603,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：江苏省中医药管理局科技项目(LZ11120):益气养阴;清肺通腑法对小儿久咳防治效应及其机制研究;负责人:周春祥

摘　　要：目的:观察小儿久咳方对小儿久咳的作用。方法:将96例中医诊断为气阴两虚、肺热腑实之虚实错杂证,西医诊断为肺炎支原体肺炎(MPP)感染后恢复期的久咳患儿,随机分为中药组和对照组,各48例。中药组运用益气养阴、清肺通腑的小儿久咳方治疗,对照组运用顺尔宁治疗,两组分别于治疗前1日及治疗后30 d,观察临床疗效评分及CD4+T淋巴细胞、CD8+T淋巴细胞水平及CD4/CD8比值。结果:两组经30 d治疗后,患儿的临床疗效评分皆有显著改善(P<0.01),中药组优于对照组(P<0.01);与治疗前相比,治疗后中药组CD4+T淋巴细胞、CD8+T淋巴细胞水平及CD4/CD8比值显著提高(P<0.05),对照组CD4+T淋巴细胞水平及CD4/CD8比值显著提高(P<0.05),而CD8+T淋巴细胞水平无改变,中药组对CD4+T淋巴细胞、CD8+T淋巴细胞水平的调节作用优于对照组(P<0.01)。结论:小儿久咳方能有效改善小儿久咳患儿临床症状并调节免疫功能。This study was aimed to observe the effect of Pediatric Long-term Cough Decoction in the treatment of long-term cough among children. A total of 96 cases were diagnosed in traditional Chinese medicine （TCM） as qi-yin deficiency, and lung-heat accumulation with constipation. The western medicine diagnosis was mycoplasma pneumoniae pneumonia （MPP） infection in the recovery period after chronic cough. All cases were randomly divided into the TCM group and control group, with 48 cases in each group. In TCM group, the Pediatric Long-term Cough Decoction was used to supplement qi and nourish yin, clear away the lung-heat and excrete feces. In the control group, montelukast was used. For both groups, clinical effect of score and CD4＋ T lymphocytes, CD8＋ T lymphocytes and CD4＋/CD8＋ ratio were observed one day before treatment and thirty days after treatment. The results showed that after thirty-day treatment, the clinical effect of score in both groups was obviously improved （P 〈 0.01）. The TCM group was better than the control group （P〈 0.01）. Compared with pretreatment, the posttreatment CD4＋ T lympho-cytes, CD8＋ T lymphocytes and CD4＋/CD8＋ ratio in TCM group were obviously improved （P 〈 0.05）. The CD4＋ T lymphocytes and CD4＋/CD8＋ ratio in the control group were obviously improved （P 〈 0.05）. However, there was no change on the CD8＋ T lymphocytes. The regulation effect on CD4＋ T lymphocytes and CD8＋ T lymphocytes of TCM group was better than the control group （P〈 0.01）. It was concluded that the Pediatric Long-term Cough Decoction can effectively improve clinical symptoms of chronic cough in children and regulate immune function.

关 键 词：益气养阴 清肺通腑法 小儿久咳 临床疗效 免疫调节 

分 类 号：R392[医药卫生—免疫学]