慢性心力衰竭患者IL-6、sICAM-1的血浆表达及与BNP和心功能关系的相关性研究  

Expression of IL-6,sICAM-1 in plasma of CHF patients and the relationship with BNP and heart function

作　　者：熊彬[1] 魏任雄[2] 陈国方[3] 

机构地区：[1]宁波市第二医院检验科,浙江宁波315010 [2]浙江中医药大学附属宁波中医院检验科,浙江宁波315010 [3]宁波市第二医院心内科,浙江宁波315010

出　　处：《中国卫生检验杂志》2013年第14期2951-2952,2960,共3页Chinese Journal of Health Laboratory Technology

摘　　要：目的检测慢性心力衰竭患者血浆B型利钠肽(BNP)以及白介素-6(IL-6)和可溶性细胞粘附分子-1(sICAM-1)的血浆表达水平,按HAYA心功能分级将慢性心力衰竭患者分组,统计分析各组炎症因子及BNP的血浆表达水平,探讨炎症在慢性心力衰竭发生、发展中的影响。方法 BNP用免疫荧光分析法,IL-6、sICAM-1用ELISA方法。结果慢性心力衰竭患者BNP、IL-6以及sICAM-1的血浆表达水平明显高于健康对照组(P<0.01),慢性心力衰竭不同心功能分级组BNP、IL-6以及sICAM-1的水平比较分别呈现不同的统计意义。结论炎症是慢性心力衰竭发生、发展中的重要影响因素。Objective To detect the expression levels of B type natriuretic peptide（ BNP）, interleukin -6（IL -6） and soluble vascular cell adhesion molecular 1 （ sICAM - 1 ） in patients with chronic heart failure （CHF）. Grouping the patients by New York Heart Association function class, the differential expressi9n of inflammatory factors and BNP in each group was analyzed to explore the impact of inflammation on the occurrence and development of CHF. Methods Fluorimetry was used to detect BNP expression level, while that of IL - 6 and sICAM - 1 was measured by ELISA. Results The expression levels of BNP, IL - 6 and sICAM - 1 were significantly higher compared to those of health control group（ P 〈 0. 01 ） , and those of BNP, IL - 6 and sI- CAM - 1 showed different statistical significance between the groups divided by HAYA. Conclusion Inflammation plays an important role in the occurrence and development of CHF.

关 键 词：慢性心力衰竭 B型利钠肽 白介素-6(IL-6) 可溶性细胞粘附分子-1 

分 类 号：R541.6[医药卫生—心血管疾病]