氟芬那酸丁酯软膏联合地氯雷他定治疗多形性日光疹51例疗效观察  

Effect of Buty Flufenamate Ointment Combined with Desloratadine in the Treatment of 51 Cases Patients with Pol- ymorphous Light Eruption

作　　者：李芃[1] 姚鹏[1] 

机构地区：[1]武汉市中心医院皮肤科,湖北武汉430013

出　　处：《中国皮肤性病学杂志》2013年第12期1314-1316,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的观察氟芬那酸丁酯软膏治疗多形性日光疹(polymorphous light eruption,PLME)的临床疗效和安全性。方法选取PLME患者93例,随机分为两组,两组患者的年龄、性别、病程、发病季节、临床表现等均具有可比性。治疗组(51例)予氟芬那酸丁酯软膏外搽患处,2次/d;对照组(42例)予糠酸莫米松乳膏外搽患处,1次/d。两组均予地氯雷他定片5mg口服,1次/d。10d为一疗程,共4个疗程。每个疗程结束时评价两组有效率。全部疗程结束后,评价两组患者的皮肤病生活质量指数(DLQI)。结果治疗组第10天、第20天、第30天、第40天有效率分别为31.37%,66.67%,78.43%和84.31%,对照组分别为47.62%,69.05%,76.19%和80.95%,两组患者各观测点有效率的差异均无统计学意义(P均>0.05)。治疗组和对照组患者DLQI均有显著降低,与治疗前相比,差异有统计学意义(P<0.001),治疗后治疗组和对照组DLQI差异均无统计学意义(P>0.05)。两组均未出现严重的不良反应。结论氟芬那酸丁酯软膏联合地氯雷他定治疗PLME疗效好,安全性高。Objective To evaluate the efficacy and safety of buty flufenamate cream combined with desloratadine in treatment of patients with Polymorphous Light Eruption. Methods Ninty three patients diagnosed as poly- morphous light eruption were recruited and randomized into treatment group and control group. There was no significant difference in age, gender, disease course, onset season and clinical manifestation between two groups. The treatment group（51 cases） were topically applied with buty flufenamate ointment twice a day, and control group（42 cases） with 0.1% mometasone furoate cream once a day. Patients in both groups re- ceived desloratadine（Smg per tablet）, 1 tablet per day. Total treatment period consisted of 4 courses, each lasting for 10 days. Efficacy rates were compared between two groups at the end of each course. Dermatology life quality indexs （DLQI） were evaluated before and after treatment. Results For all observation points （ l0＇h day, 20th day ,30＇h day, 40＇h day） , no significant differences were observed for effective rates between treatment group（31.37%, 66.67%, 78.43% and 84.31% respectively） and control group（47.62%, 69. 05% , 76.19% and 80.95%, respectively） （P 〉 0.05 ）. A significant decrease of DLQI was observed for both groups（P 〈0. 001 ） and no significant difference was noted for post-therapy DLQI between two groups （ P 〉 0.05 ）. No serious adverse events occurred in both groups. Conclusion A therapy of buty flufenamate ointment combined with desloratadine is effective and safe for patients with polymorphous light eruption.

关 键 词：氟芬那酸丁酯软膏 地氯雷他定 多形性日光疹 生活质量评价 安全性 

分 类 号：R758.14[医药卫生—皮肤病学与性病学]