Bombyx mori bidensovirus:The type species of the new genus Bidensovirus in the new family Bidnaviridae  

作　　者：HU ZhaoYang LI GuoHui LI GuangTian YAO Qin CHEN KePing 

机构地区：[1]Institute of Life Sciences, Jiangsu University

出　　处：《Chinese Science Bulletin》2013年第36期4528-4532,共5页

基　　金：supported by the National Natural Science Foundation of China(31272507,31270192 and 31000080);Startup Scientific Research Fund from Jiangsu University for Advanced Professionals(11JDG048);National Basic Research Program of China(2012CB114604);China Postdoctoral Science Foundation(2011M500854)

摘　　要：Bombyx mori bidensovirus(BmBDV),which had been assigned to Densovirinae in Parvoviridae previously,replicates mainly in silkworm midgut columnar cells and causes the fatal flacheric disease.In contrast to parvovirus,this virus possesses two single-stranded DNA genome segments and encodes a putative protein-primed DNA polymerase.The accumulating evidence suggests that it has unique characteristics different to parvovirus and adopts its own mechanisms for replication.So far,little is known about the replication mechanisms of BmBDV.In this review,we focus on the pathology associated with this virus and the viral biology such as viral genome structure,viral genes,and viral replication and expression strategies.Bombyx mori bidensovirus （BmBDV）, which had been assigned to Densovirinae in Parvoviridae previously, replicates mainly in silkworm midgut columnar cells and causes the fatal flacheric disease. In contrast to parvovirus, this virus possesses two single-stranded DNA genome segments and encodes a putative protein-primed DNA polymerase. The accumulating evidence sug- gests that it has unique characteristics different to parvovirus and adopts its own mechanisms for replication. So far, little is known about the replication mechanisms of BmBDV. In this review, we focus on the pathology associated with this virus and the viral biology such as viral genome structure, viral genes, and viral replication and expression strategies.

关 键 词：家蚕 模式种 细小病毒 复制机制 家族 新属 DNA聚合酶 基因组结构 

分 类 号：Q503[生物学—生物化学]