六味地黄粉体吸湿性及其物理性质相关性研究  

Hygroscopicity of Liuwei Dihuang powder and its correlation of physical properties

作　　者：张利[1,2] 胡容峰[1,2,3,4] 

机构地区：[1]安徽中医药大学,安徽合肥230038 [2]省部共建新安医学教育部重点实验室,安徽合肥230038 [3]安徽省“115”新安医药研究与开发创新团队,安徽合肥230038 [4]安徽省中药研究与开发重点实验室,安徽合肥230038

出　　处：《中草药》2013年第21期2977-2981,共5页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81173556);国家科技支撑计划--新安医家名方验方筛选评价研究(2012BAI26B03);安徽省学术和技术带头人及后备人选学术科研活动经费资助项目(皖人社秘[2011]381号-26);安徽省高层次人才创新创业资金(2009Z061)

摘　　要：目的研究六味地黄提取物的吸湿特性,及抗张强度与其含水量、休止角、临界相对湿度(CRH)和卡氏指数等其他物理性质相关性。方法以六味地黄提取物为模型,以不同的添加方法添加不同的辅料,绘制各粉体的吸湿曲线图,考察其吸湿特性,应用多元线性回归法分析抗张强度与休止角、卡氏指数等其他物理性质的关系。结果添加辅料的六味地黄提取物吸湿性均得到改善,在考察范围内抗张强度与休止角、压缩指数、松密度、吸湿加速度呈负相关,与水溶性、干燥含水量、CRH、平衡吸湿量、吸湿初速度呈正相关。结论六味地黄粉体的物理特性直接影响其片剂成型性。Objective To investigate the hygroscopic properties of Liuwei Dihuang extract, and the correlation between the tensile strength and physical properties such as moisture content, angle of repose, critical relative humidity （CRH）, and Karnofsky index. Methods Liuwei Dihuang extract was used as a model, added with various excipients in different ways, and their hygroscopic properties were examined. Using the method of multiple linear regression analysis, the correlation between tensile strength and the physical properties of Liuwei Dihuang raw materials was studied. Results The hygroscopicity of Liuwei Dihuang extract with various excipients was improved, negatively correlated with angle repose, compression index, bulk density, and moisture acceleration, and positively correlated with water solubility, water content, CRH, equilibrium moisture content, and initial velocity of hygroscopicity. Conclusion The physical properties of Liuwei Dihuang powder affects the tensile strength of its tablets formed directly.

关 键 词：六味地黄 吸湿性 物理性质 抗张强度 多元回归分析 相关性 

分 类 号：R283.6[医药卫生—中药学]