复方栀子凝胶的处方工艺研究  

Study on prescription technology of Compound Zhizi Gel

作　　者：党翔吉 魏立明[2] 韩姗姗[2] 李辉[2] 焦海胜[1] 

机构地区：[1]兰州大学第二医院药学部,甘肃兰州730030 [2]兰州大学药学院,甘肃兰州730000

出　　处：《中草药》2013年第21期2982-2987,共6页Chinese Traditional and Herbal Drugs

摘　　要：目的优化复方栀子凝胶处方组成,确定复方栀子凝胶的最佳处方工艺。方法采用正交试验方法,通过耐寒耐热实验,对凝胶处方的基质进行优化筛选,以涂展性、光泽性、均匀度、离心稳定性以及体外透皮释放性能为指标,对处方的其他辅料进行优化筛选。结果最佳的凝胶处方组成为卡波普940 1.5%,丙二醇1.5%,甘油3%,三乙醇胺5%,氮酮5%。结论优化后的处方更加可靠、稳定,能够满足复方栀子凝胶的生产要求。Objective To optimize the prescription of Compound Zhizi Gel （CZG） and to optimize the prescription technology of CZG. Methods Orthogonal test, cold-resistant and heat-resistant tests were used to optimize the prescription technology. Using spreadability, glossiness, evenness, centrifugal stability, and in vitro transdermal diffusion as indexes, other excipients of prescription were optimized. Results The optimal CZG prescription was Carbopo1940-glycerin-propylene glycol-triethanolamine-azone （1.5% ： 1.5% ： 3% ： 5% ： 5%）. Conclusion The optimized prescription is reliable and stable. It could meet the production requirements of CZG.

关 键 词：复方栀子凝胶 丹皮酚 阿魏酸 栀子苷 氮酮 透皮释放 

分 类 号：R283.6[医药卫生—中药学]