不同营养方式治疗对重症急性胰腺炎患者预后的影响  

Effects of Different Nutritional Therapy on the Prognosis of Patients with Severe Acute Pancreatitis

作　　者：朱敏[1] 袁昌琼[1] 杨慧英[1] 腾菲[1] 郭晓东[2] 李明阳[3] 

机构地区：[1]解放军总医院南楼消化科,北京100853 [2]解放军第302医院,北京100039 [3]解放军总医院消化内镜诊疗科,北京100853

出　　处：《现代生物医学进展》2013年第28期5502-5504,共3页Progress in Modern Biomedicine

基　　金：解放军总医院苗圃基金面上项目(11KMM21)

摘　　要：目的:通过临床试验,比较不同营养方式治疗重症急性胰腺炎的效果,并分析不同方法对患者预后的影响。方法:选取我院在2011年11月至2012年11月收治的150例重症急性胰腺炎患者,随机分为三组:肠外营养组(PN);肠内营养组(EN);肠外+肠内营养组(PN+EN),每组50例。仔细观察三组患者在住院接受营养治疗期间的情况,分别在第5天和第10天检测三组患者的血淀粉酶和免疫指标,并且对三组患者的住院时间、住院费用、消化道不良反应等指标进行比较。结果:在接受不同的营养支持后,(PN+EN)组患者的血淀粉酶、免疫指标、住院时间、住院费用、消化道不良反应等指标可见明显下降;与PN组和EN组相比差异显著,有统计学意义(P<0.05)。结论:重症急性胰腺炎患者接受营养支持对治疗其疾病非常重要,对重症胰腺炎患者实施肠外+肠内的营养支持更加安全有效,便于患者吸收,有助于保护肠道粘膜屏障,降低感染率,改善患者的身体状况,非常值得临床上广泛推广应用。Objective： To compare the clinical efficacy of different nutritional methods on the treatment of severe acute pancreatitis by a clinical trial, and analyze the effects brought by different methods on the prognosis of patients. Methods： 150 patients who were diagnosed and treated with severe acute pancreatitis in our hospital from November 2011 to November 2012 were randomly divided into three groups：PN Group （50 cases）; EN Group （50 cases）; PN＋EN Group （50cases）. We comprehensively observed the situations of patients when they were treated by different nutritional methods, and detected the AMS and immune index of patients on the fifth and tenth day respectively, then compared their time for hospitalization, costs and adverse reactions to alimentary canal. Results： There were obvious down-regulations about the AMS, immune index, hospitalization time, costs and adverse reactions of patients in PN＋PE group. When compared with PN group and PE group, there was statistically significant difference（P〈0.05）. Conclusion： It is essential for patients with severe acute pancreatitis to adopt nutritional therapy. It is suggested that the PN＋PE nutritional method could be more safe and eff- ective with the advantages of easy to absorb, help to protect the obstacles of alimentary canal and minimize the infection so as to improve the quality of patients. It is well worthy of promoting for the treatment of severe acute pancreatitis in the clinical field.

关 键 词：重症急性胰腺炎 肠外营养 肠内营养 临床效果 

分 类 号：R657.51[医药卫生—外科学]