囊泡转运蛋白SM蛋白家族的研究进展  

Research Progress on Vesicle Trafficking Proteins SM Protein Family

作　　者：刘毅华[1] 高向东[1] 徐晨[2] 

机构地区：[1]中国药科大学生命科学与技术学院,江苏南京210009 [2]北京三元基因工程有限公司,北京102600

出　　处：《现代生物医学进展》2013年第28期5595-5600,共6页Progress in Modern Biomedicine

基　　金：北京市科委基础研究专项课题资助项目(Z0005187040621)

摘　　要：真核细胞中含有多种不同功能的转运囊泡。虽然转运途径和携带物质各异,但细胞转运的基本分子机制却呈现出高度相似性和保守性。大多数转运途径都需要一种SNARE(Soluble NSF Attachment Protein Receptor)蛋白质复合体介导转运膜泡与靶膜的融合。同时,另一个蛋白家族,Sec1/Munc18蛋白(SM蛋白)也在囊泡运输中发挥重要作用。但是相比于对SNARE蛋白的认识的一致性,在不同的研究中SM蛋白的功能及其与SNARE复合体的相互作用方式却不尽相同。以下综述近年来有关SM蛋白结构和功能的研究进展,并归纳SM蛋白分子的作用机制、功能以及应用。： Most cells contain a variety of transport vesicles with different functions. Despite the different transport routes and different substances carried, the basic molecular mechanisms of cellular transport appear to be rather similar and conserved in evolution. Most transport routes need a protein complex called Soluble NSF Attachment Protein Receptor （SNARE） to induce the fusion of vesicle and target membrane. It is also evident that another protein family, the Sec 1/Munc 18 proteins （SM proteins）, plays a prominent role in vesicle trafficking. But, in contrast to the clarity about SNARE proteins, different experimental systems obtained different data on the function of SM proteins and the interaction mode between SM proteins and SNARE proteins. The research progress of the structure and function of SM proteins are reviewed and the molecular mechanisms, functions and applications of SM proteins are summarized in this paper.

关 键 词：SM蛋白 SNARE蛋白 囊泡运输 分泌调节 

分 类 号：Q591.9[生物学—生物化学] Q343.3