京尼平交联在胸心外科组织工程领域的应用与研究进展  

Research Progress of Genipin Cross-linking in Tissue Engineering in the Field of Cardiothoracic Surgery

作　　者：孙飞 潘枢 史宏灿 

机构地区：[1]扬州大学临床医学院胸外科,江苏扬州225001

出　　处：《中国胸心血管外科临床杂志》2013年第6期714-718,共5页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金资助项目(30672080;30972968;81170014);江苏省"青蓝工程"学术带头人基金资助项目(20081215);江苏省"六大人才高峰"高层次人才基金资助项目(2009128)~~

摘　　要：脱细胞组织工程支架具有与原生组织相似的结构体系和机械性能,具有良好的生物相容性、有利于细胞的粘附生长、诱导血管再生,且无免疫原性。而京尼平(Genipin)具有抗炎、抗血栓、抗氧化性,抑制血管及内皮细胞炎性活化,并能有效提高生物支架机械性能、抑制炎症并减小降解率。通过京尼平交联脱细胞基质能进一步改善组织工程基质的相关性能,有助于促进组织工程更好地应用于胸心外科临床实践。现对京尼平在胸心外科组织工程领域中的研究现状、展望和可能的前景进行综述。Decellularized tissue engineering scaffolds appear to have the properties of similar structure and mechanical characteristics to native tissues，good biocompatibility，suitability for cell adhesion，growth and angiogenesis induction，and non-immunogenicity. Genipin has anti-inflammatory，antithrombotic and antioxidative features which can considerably suppress vascular and endothelial inflammatory activation，increase mechanical strength of biological scaffolds，inhibit inflammatory response and decrease degradation rate of biological scaffolds. By cross-linking with decellularized matrices，Genipin can further improve corresponding performance of tissue engineering matrices，which is very helpful to promote the application of tissue engineering into clinical practice of cardiothoracic surgery. This review focuses on recent research process and possible prospects of Genipin cross-linking in tissue engineering in the field of cardiothoracic surgery.

关 键 词：京尼平 组织工程 生物相容性 机械性能 交联 

分 类 号：R655[医药卫生—外科学]