RA患者IL-7检测及其临床意义的初步探讨  

Preliminary discussion of IL-7 detection on RA patients and its clinical significance

作　　者：朱玉静[1] 张缪佳[1] 柯瑶[1] 吴云娟[1] 

机构地区：[1]南京医科大学第一附属医院风湿免疫科,210029

出　　处：《中国现代药物应用》2013年第22期1-3,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探索血清IL-7对RA诊断、病情活动性评估和预后判断的意义。方法用ELISA法检测42例RA患者以及20例健康体检者血清IL-7浓度,比较各组间差异;并与临床资料及实验室检查进行相关性分析。结果重度活动期RA患者血清IL-7浓度明显高于低-中度活动期RA患者(P=0.013)和健康对照组(P=0.001),而低-中度活动期RA患者组对比健康对照组差异无统计学意义(P=0.352);且与ESR、CRP呈正相关。结论 IL-7以≥1.72 pg/ml为阳性,对判断RA活动性有较高的特异性及敏感性,有可能成为RA病情活动度的指标。Objective To investigate the expression of IL-7 in serum of patients with rheumatoid arthritis（RA） and to identify its clinical significance in RA. Methods The levels of IL-7 in serum were measured by enzyme-linked immunosorbent assay（ELISA）in 42 patients with RA, and 20 nomal controls. And their clinical significance was analysed with corresponding clinical materials. Results The serum IL-7 levels in severe RA patients were signficantly higher than that in mild RA patients（P=0.013）and normal controls（P=0.001）. The optimal operating point of IL-7 was 1.72 pg/ml. There were significant correlations between serum IL-7 and CRP（r=-0.437, P=0.048）and ESR（r=-0.459, P=0.037）. Conclusion IL-7 could serve as a supplemental parameter in diagnosing RA, especially in severe RA. It may help evaluate the disease activity of RA.

关 键 词：IL-7 类风湿性关节炎 

分 类 号：R593.22[医药卫生—内科学]