新型联噁二唑啉类化合物的合成及其抗菌活性  

Synthesis and Antibacterial Activities of Novel Bi-oxadiazoline Compounds

作　　者：陈桐滨[1] 潘庆能[1] 方桂坡 谢光华[1] 

机构地区：[1]韩山师范学院化学系,广东潮州521041

出　　处：《合成化学》2013年第6期698-700,共3页Chinese Journal of Synthetic Chemistry

基　　金：广东省科技厅项目(2008B080701017);韩山师范学院项目(LY201305);韩山师范学院"大学生创新性实验计划"资助项目

摘　　要：以草酸二甲酯为起始原料,设计并合成了8个新型的联噁二唑啉类化合物(1a^1h),其结构经1H NMR,IR和MS表征。初步抗菌活性测试结果表明,1a^1h在用药量为1 mg·mL-1时对大肠杆菌、金黄色葡萄球菌和枯草芽孢杆菌有良好的抑制作用。Eight novel bi-oxadiazolines （ la ~ lh） were designed and synthesized from oxalic acide dimethyl ester. The structures were characterized by 1H NMR, IR and MS. The in vitro growth pre- liminary fungicidal activity tests showed that la ~ lb exhibited certain anti-bacterial activities against Escherichia coli, Staphyloccocus aureus and Bacillus subtilis at 1mg· mL-1.

关 键 词：草酸二甲酯 联噁二唑啉 合成 抗菌性能 

分 类 号：O626.2[理学—有机化学]