2-溴-3-甲基-1,4-二甲氧基萘的合成工艺改进  

Process Improvement on the Synthesis of 2-Bromo-3-methyl-1,4-dimethoxynaphthalene

作　　者：焦淑清[1] 陶轶[1] 杨明波[1] 李洪泽[1] 

机构地区：[1]佳木斯大学药学院黑龙江省生物药制剂重点实验室,黑龙江佳木斯154007

出　　处：《合成化学》2013年第6期754-756,共3页Chinese Journal of Synthetic Chemistry

摘　　要：以2-甲基-1,4-萘醌为原料,经溴代,还原和甲基化反应合成了维生素K2的重要中间体——2-溴-3-甲基-1,4-二甲氧基萘,总收率72.2%,其结构经1H NMR和MS确证。2-Bromo-3-methyl-1,4-dimethoxynaphthalene, a key intermediate of Vitamin K2, was syn- thesized by a three-step reaction of bromination, reduction and methylation from 2-methyl-1,4-naph- thoquinone in overall yield of 72.2%. The structure was confirmed by 1H NMR and MS.

关 键 词：2-溴-3-甲基-1 4-二甲氧基萘 维生素K2 合成 工艺改进 

分 类 号：O625.31[理学—有机化学]