奥硝唑β-环糊精包合物的制备  

Preparation of ornidazole β-cyclodextrin inclusion complexes

作　　者：常相娜[1] 沈文[1] 周璐璐[2] 张莉[1] 

机构地区：[1]陕西科技大学生命科学与工程学院,陕西西安710021 [2]中航工业哈尔滨二四二医院,黑龙江哈尔滨150066

出　　处：《陕西科技大学学报（自然科学版）》2013年第6期132-135,共4页Journal of Shaanxi University of Science & Technology

基　　金：陕西省教育厅专项科研计划项目(2013JK0767);陕西省科技厅自然科学基础研究计划项目(2011JM2005);陕西科技大学自然科学基金项目(ZX07-19;ZX10-21)

摘　　要：采用饱和溶液法制备奥硝唑与β-环糊精的包合物,采用显微镜法、红外光谱法对包合物进行了鉴定,并评价包合物溶解性与稳定性.通过L9(34)正交试验设计考察包合物的制备工艺.试验结果表明:奥硝唑与β-环糊精可形成可溶性包合物,可提高奥硝唑的溶解性和稳定性.包合物的最佳制备条件为奥硝唑∶β-环糊精=1∶1,包合时间为3h,包合温度为60℃.包合物收率为73.10%,包合率为24.53%.Ornidazole β-cyclodextrin inclusion complexes were prepared by saturated water so lution,and their structures were characterized by microscope and IR. The solubility and sta- bility of ornidazole ffcyclodextrin inclusion complexes were evaluated. The preparation condi- tion were selected by L9 （34 ） orthogonal experimental design. Results have shown that ornidazole and ffcyclodextrin can form inclusion complex,and the aqueous solubility and sta- bility were increased when ornidazole was included by β-cyclodextrin. The optimum prepara- tion conditions of ornidazole β-cyclodextrin inclusion complexes were established as follows： the quality ratio of ornidazole andffcyclodextrin was 1 ： 1,reaction time for was 3 h,inclu- sion temperature was 60 ℃,and yield was 73. 10%,the inclusion rate of the complex was 24.53%.

关 键 词：奥硝唑 伊环糊精 包合物 制备工艺 

分 类 号：R97[医药卫生—药品]