喜树与喜树碱开发利用进展  

THE DEVELOPMENT IN RESEARCH ON CAMPTOTHECA ACUMINATA AND UTILIZATION OF CAMPTOTHECIN

作　　者：冯建灿[1] 张玉洁 谭运德 张文杰 

机构地区：[1]河南农业大学林学系,郑州450002 [2]河南省林业技术推广站,郑州450008

出　　处：《林业科学》2000年第5期100-108,共9页Scientia Silvae Sinicae

摘　　要：自发现喜树中的喜树碱具有抗癌活性以来 ,科技工作者对喜树和喜树碱进行了较为系统的研究。对喜树的研究 ,主要体现在对喜树生长发育的基本规律、树体中喜树碱及其类似物的含量及分布规律、部分环境因子对树体内喜树碱含量的影响、组织培养与悬浮培养技术等方面的研究 ,指出收获幼嫩枝梢是实现提取原料快速生产的一条有效途径。而对喜树碱的研究则集中在对喜树碱的抗癌机理、分子结构、结构与抗癌效果、生产工艺等方面 ,人工合成也取得了可喜的进展 ,但一直没有得到左旋的喜树碱。以喜树碱及其类似物为基础的药物开发已进入第 3代 ,临床试验和效果观察更是成绩卓著。本文对几十年来国内外上述几方面的研究进行了综述 ,并对未来的研究方向进行了展望。Since it was found that Camptotheca acuminata Dencne contains camptothecin with anti\|cancer mechanism,scientists have done a great of works on C.acuminata and camptothecin research.On C.acuminata the research focused on the tree's growth characteristic,the distribution and content of camptothecin in the different organs,some environmental factors' effect on the material's camptothecin content,the techniques of micropropagation,suspension culture and others.The results showed that it was an effective way to supply high camptothecin content material by harvesting young branch.At the same time,more attention has been paid on techniques for camptothecin extraction,molecular structure of camptothecin,the relationship between the structure and the effect of anti\|cancer activity.Artificial synthesizing has been made great progress, but levo\|camptothecin still has not been synthesized.Three generations of medicines based on camptothecin and its analogs have been developed,clinic trials also made great progress.All these aspects are reviewed in this paper.The authors also pointed out the future researching fields.

关 键 词：喜树 喜树碱 抗癌 开发利用 

分 类 号：Q949.761.8[生物学—植物学] R282.710.2[医药卫生—中药学]