股动脉置管持续微量动脉泵给药治疗糖尿病足病的疗效观察  

The observation of therapeutic efficacy of continuous infusion of alprostadil through femoral artery pump for diabetic foot disease

作　　者：蒋成霞 曹跃勇[2] 潘俊江[3] 赵少勇[3] 周娟[1] 武金文[1] 刘欣[1] 华燕[1] 杨祖蓉[1] 姚兰[1] 谢书和 

机构地区：[1]四川省宜宾市第二人民医院内分泌科,644000 [2]四川省宜宾市第二人民医院放射科,644000 [3]四川省宜宾市第二人民医院普外科,644000 [4]宜宾市南溪区人民医院内科

出　　处：《中国糖尿病杂志》2013年第12期1078-1080,共3页Chinese Journal of Diabetes

基　　金：四川省卫生厅科研项目(070013)

摘　　要：目的观察微量动脉泵持续股动脉输注前列地尔治疗糖尿病足病(DF)的疗效。方法 DF患者56例随机分为微量泵治疗组和对照组,治疗组给予微量泵持续股动脉输注前列地尔,对照组予静脉输注前列地尔,均持续3～7d。观察两组冷感或红肿减轻例数及侧支循环建立例数。结果治疗组病变肢体皮温升高多于对照组,比较差异有统计学意义[(2.52±0.70)vs(0.07±0.26)℃,t=17.61,P=0.002]。治疗组患肢溃疡愈合情况好于对照组(P=0.001)。结论微量动脉泵持续股动脉输注前列地尔治疗Foutain 3级及3级以上DF,可使患肢血管建立侧支循环,改善足部血供。Objective To observe the therapeutic efficacy of continuous intra-femoral artery infusion of alprostadil by femoral artery pump for diabetic foot disease.Methods 56 patients with type 2 diabetes mellitus plus diabetic foot disease were divided into treatment group and control group.The treatment group received continuous infusion of alprostadil through femoral artery pump and control group received intravenous injection of alprostadil for 3～7 days.We observed the number of cases with improvement of cold feeling,redness and swelling as well as collateral circulation establishment in treatment group versus control group.Results After treatment,the skin temperature were significantly higher in the treatment group than in control group [（2.52±0.70） vs （0.07±0.26）℃,t=17.61,P=0.002].The treatment group is better than control group in ulcer healing（P=0.001）.Condusion The treatment to diabetic foot disease of Foutain 3 level and more than 3 levels by continuous infusion of alprostadil by femoral artery pumps can promote collateral circulation establishment in patients with DFD,and improve the blood supply of foot.

关 键 词：糖尿病足病 前列地尔 微量动脉泵 

分 类 号：R587.2[医药卫生—内分泌]