药对研究(Ⅲ)——药对的功效物质基础  

Research on Chinese medicine pairs(Ⅲ)——their bio-active components

作　　者：李伟霞[1] 唐于平[1] 刘立[1] 刘培[1] 宿树兰[1] 钱大玮[1] 段金廒[1] 

机构地区：[1]南京中医药大学江苏省方剂高技术研究重点实验室,江苏省中药资源产业化过程协同创新中心,江苏南京210023

出　　处：《中国中药杂志》2013年第24期4196-4202,共7页China Journal of Chinese Materia Medica

基　　金：国家科技支撑计划项目(2008BAI51B01);国家自然科学基金项目(81274058);江苏省高校自然科学重大基础研究项目(10KJA360039)

摘　　要：药对整体功效所依赖的物质已不是2味药物的简单加和,而是这2味药不同成分相互作用形成的共同体。因此,药对功效物质研究是药对配伍研究的基础,对揭示药对的配伍效应、作用机制与中药新药创制等都具有重要意义。该文基于药对配伍体外煎煮过程发生的量变与质变、药对作用于机体或和机体相关环境后的变化等方面分析并总结了近年来药对功效物质基础研究的最新进展,以期进一步推动药对现代基础与应用的系统研究,揭示药对配伍的科学实质。The total effect of Chinese medicine pair （CMP） was not the simply addition of two single herbs, but the interaction of their different components. Therefore, the research on the bio-active components of CMP is the basis of CMP compatibility study, and has important significance for revealing the compatibility effect and action mechanism, and creating traditional Chinese medicine （TCM） new drugs. This paper summed up the latest research progress of CMPon the basis of the bio-active components variation regularity of CMP from chemical solutions and content changes in vitro and the actions of CMP on bodies in vivo, in order to further drive the modern basic and applied research of CMP, and to reveal the scientific essence of CMP compatibility.

关 键 词：药对 配伍 功效物质 体外煎煮 体内变化 

分 类 号：R285.5[医药卫生—中药学]