基于热分析的炉甘石煅制研究  

Study on thermoanalysis-based calamina processing

作　　者：孟祥龙[1] 马俊楠[1] 崔楠楠[1,2] 平宇航 李坤[1] 张朔生[1] 

机构地区：[1]山西中医学院中药学院,山西太原030024 [2]湖北中医药大学药学院,湖北武汉430065

出　　处：《中国中药杂志》2013年第24期4303-4308,共6页China Journal of Chinese Materia Medica

摘　　要：采用热重（TG）技术、热质联用（TG-MS）技术、红外光谱技术（FTIR）和扫描电镜（SEM）-能谱仪（EDS）联用技术探讨炉甘石热解特性，对炉甘石热解前后相关元素含量、整体形态、官能团及挥发分等变化进行定性、定量研究，发现200～360，580～750℃为炉甘石煅制过程中药效成分变化的2个敏感温度区间，200～360℃为ZnCO3，Zn（OH）2，ZnCO3-2Zn（OH）2-H2O热失重，580～750℃为CaCO3热失重。化学反应动力学研究结果表明，具有良好的线性关系。该试验融汇物理化学及中药炮制学的相关方法及理论，阐释炉甘石煅制炮制工艺及机制，为其他中药炮制的现代研究提供一个很好的范例。Thermogravimetry （TG） , TG-MS, fourier transform infrared spectroscopy （FTIR） , scanning electron microscope （SEM）-energy dispersive spectrometer（EDS） were adopted to investigate the pyrolysis characteristics of calamina. According to the findings of the qualitative and quantitative studies on the changes in the content of relevant elements, the whole shape, the functional groups, and the volatile components of calamina before and after being pyrolyzed, the 200～360,580～750℃ were two sensitive temperature ranges related to the changes in effective component during calamina processing. Thermal weight loss was observed for ZnCO3 , Zn（OH） 2 and ZnCO3 -2Zn（OH） 2-H20 under 200-360℃ and for CaCO3 under 580-750℃. The results of studies on chemical reaction kinetics showed good linear relations. This experiment integrated relevant methods and theories of physical chemistry and science of traditional Chinese medicine processing, and interpretes calamina processing techniques and mechanism, in order to provide a good example for modern studies on other traditional Chinese medicine processing.

关 键 词：中药炮制 炉甘石 热重技术 红外光谱技术 扫描电镜-能谱联用技术 

分 类 号：R283[医药卫生—中药学]