水介质中微波促进水杨醛与苯乙腈快速合成3-苯基香豆素  

Fast synthesis of 3-phenyl coumarin from salicylaldehyde with benzene acetonitrile in aqueous medium under microwave radiation

作　　者：曾育才[1] 刘小玲[1] 梁奇峰[1] 肖丽红[1] 李岚[1] 

机构地区：[1]嘉应学院化学与环境学院,广东梅州514015

出　　处：《应用化工》2013年第12期2216-2218,2221,共4页Applied Chemical Industry

基　　金：梅州市科技局与嘉应学院资助项目(2012KJZ03)

摘　　要：在NaOH水介质中，CTABr作相转移催化剂，微波促进水杨醛与苯乙腈缩合反应，然后再酸化环合-锅法合成了3-苯基香豆素。实验表明，水杨醛10mmol、苯乙腈20mmol、CTABr0．1mmol、0．1mol／L氢氧化钠溶液20mL、微波功率300W、温度100℃时，微波反应90min后滴加浓盐酸至pH值8～9，再微波反应15min，3-苯基香豆素产率可达86．5％。3-Phenyl coumarin was synthesized by one-pot procedure by the reaction,in the presence of CTABr as phase transfer catalyst, under microwave radiation, of salicylaldehyde with phenyl acetonitrile in NaOH aqueous medium with a subsequent acid treatment of the reaction mixture. The experiment show that dosage of salicylaldehyde 10 mmol,phenyl acetonitrile 20 mmol,CTABr 0. 1 mmol,0.1 mol/L sodi- um hydroxide solution 20 mL, power of microwave 300 W, time of microwave 90 min at 100 ℃, with a subsequent acidified the reaction mixture to pH 8 -9 with concentrate HC1 and then reacted 15 rain under the condition of the microwave,3-phenyl coumarin was obtained 86.5% yield.

关 键 词：Knoevenagal缩合反应 3-苯基香豆素 水杨醛 苯乙腈 微波辐射 相转移催化 水介质反应 

分 类 号：TQ655[化学工程—精细化工]