甘露醇联合硫酸镁导泻对有机磷中毒疗效影响研究  

The clinical effect of catharsis therapy with mannitol and magnesium sulfate for the patients with organophosphate poisoning

作　　者：董广苏 

机构地区：[1]江苏省徐州市肿瘤医院ICU,徐州221009

出　　处：《现代仪器与医疗》2013年第6期49-51,54,共4页Modern Instruments & Medical Treatment

摘　　要：目的探讨甘露醇联合硫酸镁导泻治疗对口服有机磷农药中毒抢救的意义。方法回顾我院2010年10月-2013年5月收治的口服有机磷农药中毒病人105例,在复能抗胆碱治疗同时予甘露醇联合硫酸镁导泻处理,观察导泻成功率,并比较导泻成功组与未成功组之间在抢救成功率、胆碱酯酶恢复时间以及ICU入住时间的差异。结果对积极复能抗胆碱治疗的有机磷中毒患者导泻成功率为46.7%;导泻成功组与未成功组之间在胆碱酯酶恢复时间、ICU入住时间、抢救成功率方面未见明显差异。结论导泻治疗对于有机磷中毒患者的抢救意义有限,临床应用时应视患者具体情况而操作。Objective To investigate the clinical significance of catharsis with oral magnesium sulfate and mannitol for the rescue of the patients with organophosphorus pesticide poisoning. Methods Retrospective the clinical data of 158 patients with oral organophosphorus pesticide poisoning, which received treatment in our hospital during 2010.10 to 2013.05, give the patients a catharsis treatment with magnesium sulfate and mannitol based on the anticholinergic therapy, then investigated the success rate of catharsis and rescue, the dosage of atropine / PHC, and the recovery time of CHE and the hospitalization time. Results The success rate of catharsis in the anticholinergic therapy patients was just 46.7%, between the an the catharsis successful group and catharsis failure group, the recovery of CHE, the hospitalization time and the success rate of rescue not showed a difference between the two groups. Conclusions The catharsis therapy has a limited significance for the patients with organophosphate poisoning, the clinical application of the catharsis therapy should base the specific circumstances of patients.

关 键 词：有机磷中毒 导泻 甘露醇 硫酸镁 

分 类 号：R459.7[医药卫生—急诊医学]