长期小剂量罗红霉素对支气管扩张症稳定期治疗疗效观察  

The clinical efficacy of a long-term treatment with low-dose roxithromycin for the patients with stable bronchiectasis

作　　者：李为春[1] 李丽[1] 丛俊华[1] 孟华芳 严菊香[1] 刘俊[2] 

机构地区：[1]泰州市第二人民医院,泰州225500 [2]江苏省人民医院,南京210000

出　　处：《现代仪器与医疗》2013年第6期69-71,共3页Modern Instruments & Medical Treatment

摘　　要：目的观察长期小剂量罗红霉素治疗支气管扩张症稳定期患者疗效。方法将60例支气管扩张症稳定期患者随机分为治疗组和对照组,在常规口服氨溴索的基础上治疗组加用罗红霉素150mg qd,口服,疗程6个月。结果对照组6例咳嗽明显减轻,12例咳痰量减少,治疗组14例咳嗽明显减轻,26例咳痰量减少,治疗组致病菌痰菌阳性率降低,呼吸困难改善,2组比较有统计学意义(P<0.05)。结论支气管扩张症稳定期患者在常规治疗的基础上长期应用小剂量罗红霉素,可改善患者咳嗽、痰量并可降低痰菌阳性率,改善呼吸困难。Objective To observe the efficacy of low-dose roxithromycin for the long-term treatment of the bronchiectasis. Methods 60 patients with stable bronchiectasis were divided into study group and control group randomly, the patients of study control group were received a treatment with roxithromycin（150mg qd）, and the process of treatment was 6 months. Results In the control group, the cough of 6 patients was improved significantly, 12 cases patients with sputum volume decreased and the cough times of 12 patients was decreased. In the study the cough of 14patients was improved significantly, 26cases patients with sputum volume decreased and the cough time of 24 patients was decreased. The positive rate of pathogens for the study group was lower than control and the dyspnea was improved obviously, the difference between control and study group has a statistically significant（P 0.05）. Conclusions A long-term treatment with low-dose roxithromycin can provide a significant for the patients with stable bronchiectasis, such as reduce the sputum volume and number of exacerbations and improve dyspnea.

关 键 词：呼吸系统疾病 罗红霉素 支气管扩张症 

分 类 号：R562[医药卫生—呼吸系统]