血管新生抑制因子研究进展  

Progress of angiogenesis inhibitors

作　　者：张璐[1] 付毅[1] 孔炜[1] 

机构地区：[1]北京大学医学部生理学与病理生理学系,北京100191

出　　处：《转化医学研究（电子版）》2013年第3期12-27,共16页Translational Medicine Research(Electronic Edition)

基　　金：杰出青年基金(81225002);国家自然科学基金重大国际合作(81220108004)资助课题~~

摘　　要：血管系统是维持机体正常功能和内环境稳态的基础。血管新生是在已有血管的基础上生成新的血管的过程,是机体生理和病理过程中维持血管系统结构和功能正常的重要手段。体内血管新生的稳态平衡是血管新生促进因子和抑制因子共同作用的结果。血管新生抑制因子的研究对于防治肿瘤的生长和转移及异常血管增生相关疾病有潜在的临床转化意义。本文就迄今已知的内源性血管新生抑制因子及其机制方面的研究进展进行了综述。Angiogenesis means the formation of new blood vessels through proliferation and migration of endothelium. The homeostasis of vessel system is modulated by angiogenesis stimulators and inhibitors in vivo. The regulation of these factors is associated with the angiogensis-related diseases including cancer. Angiogenesis inhibitors may be applied as a potential thera-peutic target for prevention and treatment of cancer and other angiogeuesis-related diseases. In this review, we summarized a se-ries of endogenous angiogenesis inhibitors, their related mechanisms and potential applications.

关 键 词：血管新生 抑制因子 内源性 

分 类 号：R341[医药卫生—基础医学]