平阳霉素联合曲安奈德治疗疤痕疙瘩的疗效观察  

Clinical investigation of pingyangmycin and triamcinolone acetonide in the treatment of patients with keloids

作　　者：张萍[1] 陈萍[1] 黎兆军[1] 李定[1] 

机构地区：[1]广东医学院附属医院皮肤科,广东湛江524001

出　　处：《吉林医学》2013年第33期6933-6935,共3页Jilin Medical Journal

摘　　要：目的：评价平阳霉素联合曲安奈德治疗疤痕疙瘩的临床疗效和安全性。方法：将135例疤痕疙瘩患者随机分为A组、B组和C组,每组45例,A组患者采用局部注射平阳霉素及曲安奈德,1次/月,连续1~2次;B组患者局部注射曲安奈德,1次/月,连续1~2次;C组患者局部注射平阳霉素,1次/月,连续1~2次。结果：A组患者治疗后基愈率为62.22%、总有效率为88.89%;B组患者治疗后基愈率为48.89%、总有效率为68.89%;C组患者治疗后基愈率为31.11%、总有效率为64.44%。A组与B组、C组疗效比较,差异均有统计学意义（χ2=5.4040,P=0.0201;χ2=7.5155,P=0.0061）;B组与C组疗效比较,差异无统计学意义（χ2=0.2000,P=0.6547）。三组患者均无明显不良反应。结论：平阳霉素联合曲安奈德治疗疤痕疙瘩安全、有效。Objective To investigate the clinical effect and safety of pingyangmycin combined with triamcinolone acetonide in the treatment of keloids.Methods One hundred and thirty-five outpatients with keloids were divided into group A,B and C randomly.Forty-five patients in group A were treated with local pingyangmycin and triamcinolone acetonide injection once a month for 1 to 2 times.Forty-five patients in group B were treated with triamcinolone acetonide once a month for 1 to 2 times.Forty-five patients in group C were treated with pingyangmycin once a month for 1 to 2 times.Results The results of group A after treatment showed that the cured rate and total effect rate were 62.22% and 88.89%,respectively.The results of group B after treatment showed that the cured rate and total effect rates were 48.89% and 68.89% respectively. The results of group C after treatment showed that the cured rate and total effect rate were 31.11% and 64.44% respectively.The effect rate in group A was significant higher than that of group B and C（ X2= 5.4040, P = 0.0201; X2= 7.5155, P = 0.0061）.The effect rate in group B was no statistical significant with group C（X2=0.2000,P = 0.6547）.Conclusion This investigation indicates that pingyangmycin combined with triamcinolone acetonide are an efficacy and safety therapy in the treatment of keloids.

关 键 词：平阳霉素 曲安奈德 疤痕疙瘩 

分 类 号：R622[医药卫生—整形外科]