冠心病患者血浆血管性血友病因子裂解酶、生长分化因子15水平变化及相关性分析  

Correlation analysis between vWF-CP and GDF15 levels in peripheral blood of patient with coronary heart disease

作　　者：杨军[1] 王苏燕[1] 张勇[1] 王光辉[1] 邝孛[1] 江振涛[1] 文格波[1] 

机构地区：[1]南华大学第一附属医院,湖南衡阳421001

出　　处：《山东医药》2013年第43期21-23,共3页Shandong Medical Journal

基　　金：湖南省自然科学基金资助项目(11JJ2046);湖南省科技厅重点科研项目(2009SK2010)

摘　　要：目的观察冠心病患者血浆血管性血友病因子裂解酶(vWF-CP)及生长分化因子(GDF15)水平的变化,探讨两者的相关性。方法选取冠心病患者96例,其中稳定性心绞痛组(SAP组)47例,急性冠脉综合征组(ACS组)49例,选取同期无血管病变的非冠心病患者49例作为对照组,入组患者均在入院后采血。用ELISA法测定血浆vWF-CP、GDF15。结果 ACS组vWF-CP为(286.22±21.75)pg/mL、SAP组为(357.47±21.98)pg/mL、对照组为(581.85±21.52)pg/mL,组间相比,P均<0.05;ACS组GDF15为(11.30±0.51)ng/mL、SAP组为(8.37±0.54)ng/mL、对照组为(1.35±0.45)ng/mL,组间相比,P均<0.01。vWF-CP水平与GDF15水平呈负相关(r=-0.558,P<0.01)。结论冠心病患者病情不稳定时血浆vWF-CP水平降低、GDF15水平升高,两者存在显著的相关性,都与冠心病的病情有关,两者的联合检测可以更好预测冠心病患者血栓事件的发生。Objective To investigate the changes in levels of yon Willebrand factor-cleaving protease （vWF-CP） and growth differentiation factor 15 （GDF15） in peripheral blood of patient with coronary heart disease （CHD）,and then to investigate the correlation between them.Methods A total of 145 cases of patients who underwent coronary angiography were divided into three groups：49 cases of patients with non-coronary heart disease as the control group,47 cases of patients with stable angina as the SAP group and 49 cases of patients with acute coronary syndrome as the ACS group.The vWF-CP levels and GDF15 levels of all patients were measured with ELISA.Results The vWF-CP level in the ACS group [（286.22 ± 21.75） pg/mL）] was significantly lower than that in the control group [（581.85 ±21.52） pg/mL）] and in the SAP group [（357.47 ±21.98） pg/mL）] （all P＜0.05）.Compared with the control group [（1.35 ±0.45） ng/mL）],the GDF15 levels in the ACS group [（11.30±0.51） ng/mL）] and SAP group [（8.37 ±0.54） ng/mL）] were significantly higher （all P ＜ 0.01）.The vWF-CP levels had negative correlation with the GDF15 levels （r =-0.558,P ＜ 0.01）.Conclusions The vWF-CP and GDF15 levels are closely correlated with the stability condition of patients with CHD,and there is a significant correlation between them.Therefore,the combined detection of them may more effectively predict the occurrence of thrombotic events.

关 键 词：冠心病 血管性血友病因子裂解酶 生长分化因子15 血栓事件 

分 类 号：R541.4[医药卫生—心血管疾病]