盐酸齐拉西酮的电化学分析  

Electrochemical Analysis of Ziprasidone Hydrochloride in Drug

作　　者：陈立新[1] 李心恬[2] 方红[2] 周原[1] 

机构地区：[1]湖南工程学院化学化工学院,湖南湘潭411104 [2]深圳出入境检验检疫局工业品中心,广东深圳518045

出　　处：《分析科学学报》2013年第6期831-834,共4页Journal of Analytical Science

基　　金：湖南省教育厅科研基金(10C0555)

摘　　要：采用循环伏安法（CV）和差分脉冲伏安法（DPV）在玻碳电极（GCE）上对盐酸齐拉西酮进行了电化学研究，实验发现盐酸齐拉西酮在pH=3．0的B—R缓冲底液中于0．735V（VS．SCE）左右产生一个明显的氧化峰。该方法盐酸齐拉西酮在1．0×10～2．5×10。mol／L范围内与峰电流呈线性关系，检出限为2．0×10mol／L。实验考察了PH值、扫速、干扰因素、静止时间的影响。该方法操作简单、灵敏，可用于实际药品测定。对电极反应机理进行了初步探讨。Cyclic voltammetry（CV） and differential-pulse stripping voltammetry（DPV） were used to investigate the electrochemical behavior of ziprasidone hydrochloride at a glassy carbon electrode, and a method for detection of ziprasidone hydrochloride was established. The ziprasidone hydrochloride showed a sensitive oxidative peak at 0. 735V（vs. SCE） using cyclic voltammetry in a B-R solution of pH = 3.0. The effects of buffer solution, pH, accumulation time and scan rate were discussed. The peak current was linear to the concentration of maquinox ranging from 1. 0 X 10 s mol/L to 2. 5 X 10-3 mol/L with a detection limit of 2.0X 10-7 mol/L by DPV. The determination of ziprasidone hydrochloride in drugs has been performed. This method is simple and sensitive and could be used to detect real drug samples.

关 键 词：盐酸齐拉西酮 循环伏安法 差分脉冲伏安法 玻碳电极 

分 类 号：O657.1[理学—分析化学]