甲基强的松龙联合盐酸溴己新治疗儿童毛细支气管炎的疗效观察  

Efficacy Observation of Methylprednisolone Combined with Bromhexine Hydrochloride for Pediatric Capillary Bronchitis

作　　者：庄旭琴[1] 马永驰[1] 

机构地区：[1]南京医科大学附属淮安第一医院,江苏淮安223300

出　　处：《中国药房》2013年第48期4567-4568,共2页China Pharmacy

摘　　要：目的:观察甲基强的松龙联合盐酸溴己新治疗儿童毛细支气管炎的疗效。方法:将78例毛细支气管炎患儿随机均分为观察组和对照组。两组患儿均采用常规治疗,对照组患儿在常规治疗的基础上加用甲基强的松龙,观察组患儿在对照组基础上加用盐酸溴己新,两组患儿疗程均为10 d。比较两组患儿的临床疗效及不良反应发生情况。结果:治疗后,两组患儿的症状均有所缓解,观察组患儿的总有效率显著高于对照组(94.87%vs.64.10%),且观察组患儿的症状、体征的消失时间均显著短于对照组,两组比较差异均有统计学意义(P<0.05)。部分患儿在治疗过程中出现了不良反应,涉及全身多个系统,且对照组的发生率显著多于观察组(46.15%vs.15.38%),两组比较差异有统计学意义(P<0.05)。结论:甲基强的松龙联合盐酸溴己新治疗儿童毛细支气管炎的疗效优于单用甲基强的松龙,且不良反应较少,患儿依从性较好。OBJECTIVE： To observe therapeutic efficacy of methylprednisolone combined with bromhexine hydrochloride for pediatric capillary bronchitis. METHODS： 78 children patients with capillary bronchitis were randomly divided into observation group and control group. Both groups were treated with methylprednisolone on the basis of conventional treatment; observation group was additionally given bromhexine hydrochloride. Clinical efficacies of 2 groups were compared after 10-day treatment, and the occurrence of ADR was observed. RESULTS： After treatment, the symptoms of 2 groups were relieved. The total effective rate of observation group （94.87%） was significantly higher than that of control group （64.10%） ; the time of clinical symptoms and signs disappearance in observation group were shorter than control group; there was statistical significance （P〈0.05）. Some patients suffered from ADR, involving multiple body systems. The incidence of ADR in control group （46.15 % ） was obviously higher than that of observation group （15.38%）; there was statistical significance. CONCLUSIONS： Methylprednisolone combined with bromhexine hydrochloride shows good efficacy and safety in the treatment of pediatric capillary bronchitis with few ADR.

关 键 词：甲基强的松龙 盐酸溴己新 儿童毛细支气管炎 疗效观察 不良反应 

分 类 号：R562.21[医药卫生—呼吸系统]