碳负载固体酸催化合成3,4-二氢嘧啶-2-酮衍生物的研究  

Synthesis of 3,4-dihydropyrimidin-2(1H)-ones catalyzed by sulfonated carbon-based solid acid

作　　者：商宁昭 冯成[1] 张海燕[1] 周欣[1] 高书涛[1] 王春[1] 王志[1] 

机构地区：[1]河北农业大学理学院,河北保定071001

出　　处：《化学研究与应用》2013年第12期1697-1701,共5页Chemical Research and Application

基　　金：河北省自然科学基金项目(B2011204051)资助;河北农业大学理工基金项目(LG201107)资助

摘　　要：以天然多糖做碳化原料，经磺化后得到碳负载固体酸。以其为催化剂，由芳香醛、β-酮酸酯和尿素缩合制备了系列3，4-二氢嘧啶-2-酮衍生物。以乙醇为溶剂回流反应2．5～5h，产物产率在72％-89％之间。产物结构经’HNMR，IR确证。A series of 3,4-dihydrepyrimidin-2 （1 H）-ones were prepared through the Biginelli condensation reactions of aromatic aldehydes, keto ester and urea catalyzed by carbon-based solid acid, which was synthesized after pyrolysis of natural polysaccharide and subsequently functionalised with sulfonated groups. The reactions were carried out under reflux in ethanol for 2. 5-5 h. The yields of the products had between 72% - 89%. All the products had been characterized by 1H NMR and IR spectra.

关 键 词：碳负载固体酸 BIGINELLI反应 3 4-二氢嘧啶-2-酮 合成 

分 类 号：O622.4[理学—有机化学]