保留骨膜的兔桡骨缺损性骨不连模型中临界骨缺损量的研究  

Critical size defect of periosteum-retained bone defect nonunion models in radius of rabbits

作　　者：沈凯[1] 沈维军[1] 廖金辉 刘昌戎 沈为栋 

机构地区：[1]湖南农业大学动物科学技术学院,长沙410128 [2]湖南省岳阳市一人民医院老年病科 [3]湖南省岳阳市一人民医院骨科研究所

出　　处：《中华实验外科杂志》2013年第12期2661-2663,共3页Chinese Journal of Experimental Surgery

基　　金：湖南省卫生厅基金资助项目（B2005-168）

摘　　要：目的 探讨新西兰大白兔保留骨膜的桡骨缺损性骨不连动物模型中的临界骨缺损量.方法 选取40只成年新西兰大白兔,制成保留骨膜的桡骨缺损长度分别为10、15、20、25、30 mm 5组实验兔,每组8只,分别在4、8、12、16周时拍X线片,观察其骨不连情况.结果 在保留骨膜的情况下,25～30 mm缺损长度为该模型临界骨缺损量的参考值,或桡骨缺损长度达桡骨全长的35.5％～42.4％、桡骨缺损长度达桡骨横径的6～7倍时出现骨不连.结论 该数值为新西兰大白兔保留骨膜的桡骨缺损性骨不连动物模型的临界骨缺损值.Objective To study the critical size defect of periosteum-retained bone defect nonunion models in the radius of New Zealand rabbits.Methods Forty adult Zealand rabbits were selected to establish bone defect nonunion model of radius,and divide into five groups of 10,15,20,25 and 30 mm （n =8 each）.Bone nonunion was observed by X-ray examination after 4,8,12 and 16 weeks.The data were analyzed by SPSS.Results In the periosteum-retained models,the length of bone defect segment in the middle of radium was 25-30 mm.When the length of bone defect segment was 35.5％-42.2％ of that of the radius,or when the length of bone defect segment was 6-7 times of the transverse diameters,bone defect nonunion occurred.Conclusion The numerical value is of the critical size defect of this bone defect nonunion model of the radius.

关 键 词：桡骨 缺损性骨不连 临界骨缺损量 

分 类 号：R687.3[医药卫生—骨科学]