骨代谢生化指标结合Singh指数预测老年髋部骨折风险  

The quantify evaluation study on the risk of hip fracture in the elder persons by the bone biochemical markers of bone-specific alkaline phosphatase, tartrate-resistant acid phosphatase 5b, and Singh index

作　　者：唐三元[1] 梅其伟[1] 杨辉[1] 朱学敏[1] 唐天华[1] 

机构地区：[1]暨南大学附属珠海医院创伤骨科,珠海519000

出　　处：《中华实验外科杂志》2013年第12期2733-2735,共3页Chinese Journal of Experimental Surgery

摘　　要：目的 探讨骨特异性碱性磷酸酶（BALP）和抗酒石酸酸性磷酸酶-5b（TRAP-5b）以及Singh指数相结合预测老年髋部骨折发生的临床意义.方法 老年髋部骨折患者43例,对照组同龄健康体检人员43例,Singh指数测定：采用西门子Aristos VXPlus X光机拍摄骨盆X线片（包括骨折组和对照组）,进行Singh指数的分级;骨代谢生化指标测定：采用酶联免疫（ELLSA）法测定血清BALP、TRAP-5b值.对上述实验结果应用SPSS 13.0统计软件进行统计学分析.结果 骨折组和对照组血清骨代谢指标BALP、TRAP-5b含量、Singh指数,差异有统计学意义（P＜0.05）.BALP和TRAP-5b之间呈明显正相关（P＜0.05）,BALP、TRAP-5b与Singh指数均呈明显负相关（P＜0.05）.BALP和TRAP-5b以及Singh指数预测骨折风险敏感度分别为71.9％、57.1％、60.5％,三者联合预测骨折风险的敏感度为95.1％.结论 骨折组骨代谢生化指标BALP、TRAP-5b和Singh指数存在异常.BALP和TRAP-5b以及Singh指数相结合可以明显提高预测老年髋部骨折的敏感度,可以作为预测老年髋部骨折风险的敏感指标.Objective In this study,comparing and analyzing the changes of the bone metabolic markers including bone-specific alkaline phosphatase （BALP）,tartrate-resistant acid phosphatase 5b （TRAP-5b）,and Singh index in elderly the correlations between the three predictors of BALP,TRAP-5b,and Singh index were derived,and the sensitivity and specificity of predicting hip fracture were calculated.Methods Determination of the Singh index：with the help of an experienced radiology technician and three senior orthopedic surgeons,the pelvic plain film X-ray by the Siemens Aristos Vx Plus Model X-ray machine （fracture group and the control group） were analyzed,and then the Singh index of these pelvic X-ray grading were record and the mean of Singh index was judged.Determination of markers of bone metabolism：The bone metabolic markers in serum BALP,TRAP-5b were measured by enzyme-linked immunosorbent assay （ELISA） after specimen collection before uniform.SPSS 13.0 statistical software was used to analyze all of experimental data.Results The significantly different of levels of bone metabolic markers TBALP,TRAP-5b and Singh index in fracture group and the control group （P ＜0.05）.the between Bone metabolic markers BALP,and TRAP-5b is significant positive correlation （P ＜ 0.01）.the between Singh index and bone metabolic markers BALP,and TRAP-5b is significant negatively correlation （P ＜0.01）.Bone metabolic markers BALP,TRAP-5b,and Singh index sensitivity of 71.9％,57.1％ and 60.5％ ; and those joint diagnosis of hip fracture experimental sensitivity of 95.1％.Conclusion By comparing the levels of BALP,TRAP-5b and Singh index changes in fracture group with the control group,the bone metabolic markers including BALP,TRAP-5b,and Singh index in fracture group were found to be abnormal.Combination consideration of the bone metabolic markers BALP,TRAP-5b and Singh index to predict is of more meaningful than the single bone metabolism indicators of BALP,or TRAP-5b and Singh index in elderly hip fract

关 键 词：老年髋部骨折 SINGH指数 骨特异性碱性磷酸酶 抗酒石酸酸性磷酸酶5B 

分 类 号：R683[医药卫生—骨科学]