瑞舒伐他汀治疗颈动脉粥样硬化斑块的临床研究  

Clinical study of rosuvastatin in the treatment of carotid atherosclerotic plaque

作　　者：王松柏 

机构地区：[1]河南省温县第二人民医院内科,454850

出　　处：《中国实用医刊》2013年第24期87-88,共2页Chinese Journal of Practical Medicine

摘　　要：目的 探讨瑞舒伐他汀治疗颈动脉粥样硬化斑块的效果以及较其他同类他汀的优越性.方法 将153例经门诊彩超证实的颈动脉粥样硬化斑块患者随机分为两组,治疗组给予瑞舒伐他汀,对照组给予辛伐他汀,采用等剂量、相同疗程,并对同期结果进行比较.结果 治疗组在减少颈动脉粥样硬化的内中膜厚度、消除斑块以及降脂效果方面均优于对照组（P＜0.05）.结论 瑞舒伐他汀在颈动脉粥样硬化斑块治疗中较辛伐他汀具有更好的疗效,更高的依从性,更强的减少心、脑血管事件作用.Objective To investigate the effect of rosuvastatin on carotid atherosclerotic plaque and the superiority compared with other statins.Methods One hundred and fifty-three patients with carotid atherosclerotic plaque who were confirmed by color Doppler sonography were randomly divided into two groups,patients in treatment group were given rosuvastatin,and patients in control group were given simvastatin,with the same dose and course,and then the effects were compared.Results The effects of reducing intima-media thickness,eliminating carotid atherosclerosis plaque and decreasing the blood lipid level in treatment group were better than those in control group （P ＜ 0.05）.Conclusions Rosuvastatin in the treatment of carotid atherosclerotic plaques has better efficacy than simvastatin,greater compliance,and reduction of cardiovascular and cerebrovascular events.

关 键 词：颈动脉粥样硬化斑块 瑞舒伐他汀 颈动脉内中膜厚度 

分 类 号：R543.4[医药卫生—心血管疾病]