血清高迁移率族蛋白B1在儿童脓毒症中的变化及意义  

Significance of high mobility group box 1 （HMGB1） in children with sepsis

作　　者：乔晓辉[1] 黄明海[1] 罗巧二[1] 

机构地区：[1]宁波市妇女儿童医院,315012

出　　处：《中国小儿急救医学》2013年第6期599-602,共4页Chinese Pediatric Emergency Medicine

基　　金：宁波市科技计划项目（2012A610238）

摘　　要：目的 探讨血清高迁移率族蛋白B1（high mobility group box 1,HMGB1）在儿童脓毒症中的变化及临床意义.方法 检测30例健康体检儿童和46例脓毒症患儿入院第1天血清HMGB1浓度及降钙素原（procalcitonin,PCT）水平,并对脓毒症患儿进行急性生理与慢性健康状态评分（acute physiology and chronic health evaluationⅡ,APACHEⅡ）,于入院后第3、5天同样采集上述指标,将HMGB1与PCT及APACHEⅡ评分进行相关性分析.结果 儿童脓毒症组第1天、第3天及第5天血清HMGB1水平均显著高于对照组,差异有统计学意义[（26.28±1.54） ng/ml,（20.32±1.29） ng/ml,（12.84±1.06） ng/ml vs （1.52±0.29） ng/ml,P＜0.05],脓毒症组各时间点间HMGB1水平比较差异亦具有统计学意义（P＜0.05）,且血清HMGB1水平与PCT水平呈正相关（r =0.931,P＜0.05）,与APACHEⅡ评分呈正相关（r=0.915,P＜0.05）.结论 儿童脓毒症时血清HMGB1水平明显升高,且其水平与病情严重程度相关.Objective To investigate the change of serum HMGB1 level and its clinical significance in children with sepsis.Methods Serum HMGB1 and procalcitonin （PCT） levels were determined in 30 healthy individuals and 46 children with sepsis,and the acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ） scoring system was evaluated in children with sepsis.These indexes were also collected on the third and fifth days.The correlations between serum HMGB1 level and serum PCT level as well as APACHE Ⅱ score were analyzed.Results Serum HMGB1 levels in children with sepsis on the first day,the third day and the fifth day were significantly higher than those in control group,these differences were statistically significant [（26.28 ± 1.54） ng/ml,（20.32 ± 1.29） ng/ml,（12.84 ± 1.06） ng/ml vs （1.52 ± 0.29） ng/ml,P ＜0.05],HMGB1 levels among three time points were also significantly different（P ＜0.05）.The serum HMGB 1 levels were positively correlated with the PCT levels （r =0.931,P ＜ 0.05） and APACHE Ⅱ score （r =0.915,P ＜ 0.05）.Conclusion Serum HMGB1 level is obviously elevated in children with sepsis,and the level of HMGB1 can reflect the severity of sepsis.

关 键 词：脓毒症 高迁移率族蛋白B1 炎症介质 儿童 

分 类 号：R720.597[医药卫生—急诊医学]