糖皮质激素受体与儿童激素耐药型肾病综合征研究进展  

The relationship between human glucocorticoid receptor and steroid-resistant nephrotic syndrome

作　　者：张秀敏(综述)[1] 李宇宁(审校)[1] 

机构地区：[1]兰州大学第一医院儿科,兰州730000

出　　处：《中国小儿急救医学》2013年第6期647-650,共4页Chinese Pediatric Emergency Medicine

基　　金：甘肃省中药管理局基金项目（GZK-2011-23）

摘　　要：原发性肾病综合征是儿科常见的泌尿系统疾病,糖皮质激素是其首选和基础用药,然而临床中约有10％ ～ 20％的患者对激素耐药,耐药机制复杂.研究显示糖皮质激素受体参与了耐药的发生.本文就肾病综合征患儿糖皮质激素受体表达及其基因多态性做一综述.Idiopathic nephrotic syndrome is a common pediatric kidney disease,and glucocorticoid is the first choice to deal with it.However,not all children are absolutely sensitive to it,about 10 to 20 percent are steroid-resistant.Researches have shown that human glucocorticoid receptor is associating with steroid-resistant.This article summarized the expression of glucocorticoid receptor and its gene polymorphism in steroid-resistant children.

关 键 词：肾病综合征 激素耐药 糖皮质激素受体 基因多态性 儿童 

分 类 号：R726.92[医药卫生—儿科]