肺炎支原体感染与小儿哮喘的相关性分析  

Correlation between Mycoplasma pneumoniae infection and asthma in children

作　　者：孙东海[1] 洪佳璇[1] 张希[1] 李俊华[1] 

机构地区：[1]杭州市萧山区中医院儿科,浙江杭州311201

出　　处：《中华医院感染学杂志》2013年第24期6054-6055,6058,共3页Chinese Journal of Nosocomiology

基　　金：浙江省医药卫生研究基金资助项目(2013KYB226)

摘　　要：目的分析肺炎支原体(MP)感染与小儿哮喘的临床相关性,为临床治疗方案及预防提供依据。方法 2011年2月-2013年2月门诊收治的86例小儿哮喘患儿为观察组,与同期69名参加健康体检的正常儿童进行对照为对照组,两组均按要求采取空腹静脉血,应用放射免疫法测定IgE水平,同时采用酶联免疫吸附分析法测定血清中MP特异性抗体(MP-IgM)的滴度,并进行对比分析,采用SPSSl3.0软件进行统计处理。结果观察组与对照组MP-IgM阳性率分别为48.84%、21.74%,两组比较,差异有统计学意义(χ2=20.76,P<0.05);观察组MP-IgM(+)血清总IgE水平显著高于MP-IgM(-)血清总IgE水平,MP-IgM(+)外周血嗜酸性粒细胞计数明显高于MP-IgM(-),两组分别比较,差异有统计学意义(P<0.05)。结论小儿哮喘的发生与MP感染关系密切,在小儿发生哮喘时应用实验室检查肺炎支原体,并及时采用大环内酯类药物治疗对提高治疗效果及预后具有重要作用。OBJECTIVE To analyze the clinical correlation between the Mycoplasrna pneumoniae （MP） infection and the asthma in children so as to guide the clinical prevention and treatment. METHODS Totally 86 children with asthma, who were treated in the outpatient department from Feb 2011 to Feb 2013, were chosen as the observation group, while 69 healthy people who took part in the physical examination during the same period were set as the control group, then the fasting venous blood samples were collected, the level of IgE was determined with the use of radioimmunoassay, the titers of the serum MP specific antibodies （MPqgM） were measured by using enzyme-linked immunosorbent assay, the comparative study was conducted, and the statistical analysis was performed with the use of SPSS13.0 software. RESULTS The positive rate of the MP-IgM was 48. 84% in the observation group, 21.74% in the control group, the difference between the two groups was statistically signifi cant（X2 = 20.76, P〈0. 05）. In the observation group, the overall level of serum IgE of the subjects with MP-IgM tested positive was significantly higher than that of the subjects with MP-IgM tested negative; the peripheral blood eosinophil counts of the subjects with MP-IgM tested positive were significantly higher than those of the subjects with MP-IgM tested negative, the differences between the two groups were statistically significant （P〈0. 05）. CONCLUSION The occurrence of asthma in the children is closely related to the MP infection; to conduct the clini- cal laboratory examination of MP and use macrolides antibiotics for the treatment in a timely manner can improve the therapeutic effect and the clinical outcome.

关 键 词：小儿哮喘 肺炎支原体 感染 

分 类 号：R563.1[医药卫生—呼吸系统]