10天与14天含呋喃唑酮四联疗法补救治疗幽门螺杆菌的疗效比较  

Comparison of 10-day and 14-day furazolidone-containing quadruple salvage therapies for Helicobacter pylori eradication

作　　者：郑小丽[1] 许乐[1] 

机构地区：[1]北京医院消化内科,北京100730

出　　处：《中国新药杂志》2013年第23期2786-2788,2821,共4页Chinese Journal of New Drugs

摘　　要：目的:含呋喃唑酮的三联或四联疗法可用于补救治疗幽门螺杆菌(H.pylori)感染,本研究比较了2种不同疗程的呋喃唑酮四联疗法在H.pylori补救治疗中的疗效和安全性。方法:将H.pylori感染根除治疗失败的119例患者随机分为A组(59例)和B组(60例)。两组患者均给予含呋喃唑酮的四联疗法(呋喃唑酮+阿莫西林+埃索美拉唑镁肠溶片+胶体果胶铋),A组疗程为10 d,B组疗程为14 d,治疗结束后4周做13C-尿素酶呼气试验比较两组的H.pylori根除效果。结果:A组57例完成治疗及随访,其中49例补救治疗成功,其按意向治疗(ITT)H.pylori根除率和按符合方案(PP)H.pylori根除率分别为83.1%(49/59)和86.0%(49/57);B组58例完成治疗及随访,52例补救治疗成功,其ITT根除率和PP根除率分别为86.7%(52/60)和89.7%(52/58),两组根除率比较差异无统计学意义(P>0.05)。结论:对既往H.pylori根除治疗失败的患者,10 d与14 d含呋喃唑酮的四联疗法根除率无明显差异,在补救治疗时可选用10 d呋喃唑酮四联疗法。Objective： Furazolidone-based quadruple therapy can be suggested as the regimen of choice for rescue therapy in the eradication of Helicobacter pylori infection. The aim of this study was to compare the efficacy and tolerability of 10-day and 14-day furazolidone-based quadruple therapies as a second-line treatment. Methods： A total of 119 patients, in whom the initial standard PPI triple therapy had failed to eradicate Helicobacter pylori in- fection, were included in the study. Patients were randomized to receive either 10-day or 14-day therapy, including furazolidone 100 mg twice daily, esomeprazole 20 mg twice daily, amoxicillin 1 000 mg twice a day and bismuth salts 150 mg three times a day. Eradication was assessed by β C-urea breath test 4 weeks after completing the treat ment. Results： The intention-to-treat （ITT） and per-protocol （PP） eradication rates were 83.1% and 86.0% in the 10-day furazolidone-based quadruple therapy, and 86.7% and 89.7% in the 14-day therapy （P 〉 0.05） , re spectively. Conclusion： Because the 14-day furazolidone-based quadruple therapy failed to significantly increase Helicobacter pylori eradication rate, the 10-day regimen could be an effective option as rescue treatment for Helico bacter pylori infection.

关 键 词：幽门螺杆菌 呋喃唑酮 补救治疗 

分 类 号：R975[医药卫生—药品]