An overview of studies on psychological well-being in children born following assisted reproductive technologies  

作　　者：Qi-tao ZHAN Pei-pei PAN Xiang-rong XU Hang-ying LOU Yi-yun LOU Fan JIN 

机构地区：[1]Department of Reproductive Endocrinology,Women's Hospital,School of Medicine,Zhejiang University

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2013年第11期947-960,共14页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：Project supported by the National Basic Research Program(973)of China(No.2012CB944901);the National Natural Science Foundation of China(Nos.81070532 and 81070541);the Zhejiang Provincial Natural Science Foundation of China(Nos.Y2100822 andLZ13H040001)

摘　　要：Over the course of the past 35 years,assisted reproductive technologies(ARTs)have been increasingly used worldwide,while debates on their safety have been generated.Birth defects and imprinting disorders were reported in previous research.Thus,the psychological development of children born following ARTs has become a major concern nowadays.This review gives a systematic view of psychological well-being of children conceived by different types of ART,including in vitro fertilization,intracytoplasmic sperm injection(ICSI),preimplantation genetic diagnosis/screening,and in vitro maturation.The previous studies are analyzed in three sections:(1)cognitive,motor,and language developments,(2)behavior problems and socio-emotional development,and(3)parent-child relationship.We conclude that although the majority of the studies on cognitive,motor,and language developments reported comparable achievements in the ART group vs.the naturally conceived group,lower intelligence quotient(IQ)scores,worse visual-motor ability or locomotor development,and delayed receptive language competence were found in the ART group.The results on the socio-emotional development were reassuring.As for the behavior problems,a higher prevalence of behavior problems existed in ART children;moreover,ICSI children were found to be at a higher risk of autism than the general population.Meanwhile,ART parents tended to have positive parental attitudes and be more protective of their children.Some suggestions for further research are also given in this review.Over the course of the past 35 years, assisted reproductive technologies （ARTs） have been increasingly used worldwide, while debates on their safety have been generated. Birth defects and imprinting disorders were re- ported in previous research. Thus, the psychological development of children born following ARTs has become a major concern nowadays. This review gives a systematic view of psychological well-being of children conceived by different types of ART, including in vitro fertilization, intracytoplasmic sperm injection （ICSI）, preimplantation genetic diagnosis/screening, and in vitro maturation. The previous studies are analyzed in three sections： （1） cognitive, motor, and language developments, （2） behavior problems and socio-emotional development, and （3） parent-child rela- tionship. We conclude that although the majority of the studies on cognitive, motor, and language developments re- ported comparable achievements in the ART group vs. the naturally conceived group, lower intelligence quotient （IQ） scores, worse visual-motor ability or locomotor development, and delayed receptive language competence were found in the ART group. The results on the socio-emotional development were reassuring. As for the behavior problems, a higher prevalence of behavior problems existed in ART children; moreover, ICSI children were found to be at a higher risk of autism than the general population. Meanwhile, ART parents tended to have positive parental attitudes and be more protective of their children. Some suggestions for further research are also given in this review.

关 键 词：Assisted REPRODUCTIVE technologies  PSYCHOLOGICAL well-being  Behavior problems  Parent-child relationship 

分 类 号：R714.8[医药卫生—妇产科学] R395[医药卫生—临床医学]