一种镁合金可吸收肋骨髓内钉的生物力学性能  

Biomechanical properties of a magnesium alloy absorbable rib intramedullary nail

作　　者：滕继平[1] 杨志胤[1] 程佑爽[1] 倪达[1] 朱智军[1] 朱余明[1] 

机构地区：[1]上海交通大学医学院附属第三人民医院胸心外科,上海市201900

出　　处：《中国组织工程研究》2013年第48期8388-8393,共6页Chinese Journal of Tissue Engineering Research

基　　金：上海市卫生局课题专项基金(项目号:2010147)~~

摘　　要：背景:目前,临床上已成功应用于肋骨骨折内固定的手术材料主要有纯钛、镍钛记忆合金肋骨环抱接骨板和进口聚左旋乳酸可吸收肋骨髓内钉、解剖钢板等。目的:探讨新研制的镁合金可吸收肋骨髓内钉在肋骨骨折内固定中的生物力学性能,并与进口的聚左旋乳酸可吸收肋骨髓内钉内固定方法进行比较,为临床应用提供科学依据。方法:采集30根成人新鲜第5肋骨侧肋标本,行侧肋腋中线处肋骨骨折模型,分别采用AZ31B镁合金可吸收肋骨髓内钉(镁合金组),聚左旋乳酸可吸收肋骨髓内钉(聚左旋乳酸组)2种内固定方法固定,另设正常肋骨标本以作对照,运用实验应力分析手段测试各组试件的生物力学特性。结果与结论:三点弯曲强度测量结果显示,镁合金组接近正常标本(P>0.05),且镁合金组与聚左旋乳酸组差异有显著性意义(P<0.05)。扭转强度测量表明,镁合金与正常标本差异无显著性意义,比聚左旋乳酸固定更有优越(P<0.05)。拉伸实验表明,镁合金固定抗拉强度及抗拔力均优于聚左旋乳酸内固定(P<0.05)。说明镁合金可吸收肋骨髓内钉在强度和抗拉伸强度上均明显优于聚左旋乳酸可吸收肋骨髓内钉内固定,是肋骨内固定的理想固定材料。BACKGROUND： At present, the materials that are successfully applied in rib fracture internal fixation mainly include titanium, nitinol rib encircling bone bonding plate, imported poly-L-lactic acid absorbable rib nails and anatomical plate. OBJECTIVE： To study the biomechanical characteristics of new magnesium alloy absorbable rib intramedullary nail in the rib fracture fixation, and to compare with imported poly-L-lactic acid absorbable rib intramedullary nail in order to provide scientific basis for clinical application. METHODS： Thirty fresh adult fifth rib specimens were collected, and the specimens were used to make models for the middle rib fractures. The specimens were fixed with AZ31B magnesium alloy absorbable rib intramedullary nail（magnesium alloy group） and poly-L-lactic acid absorbable rib intramedullary nail（poly-L-lactic acid group）, and the normal rib specimen group was set as control. The biomechanical characteristics of the nails in each group were tested with stress analysis. RESULTS AND CONCLUSION： Three-point bending strength measurement results showed that the bending strength in the magnesium alloy group was close to the normal value of the specimen（P 0.05）, and there was significant difference in the bending strength between magnesium alloy group and the poly-L-lactic acid group（P 0.05）. Torsional strength measurement showed that there was no significant difference in torsional strength between magnesium alloy group and the normal specimens, and the results showed that the magnesium alloy was better than poly-L-lactic acid in fixation（P 0.05）. Tensile tests showed that the tensile strength andanti-pulling force of the magnesium alloy fixation were better than those of poly-L-lactic acid fixation（P 0.05）. The results indicate that the magnesium alloy absorbable rib intramedullary nail is better than poly-L-lactic acid absorbable rib intramedullary nail in strength and tensile strength, which is the ideal fixation material for rib fixation.

关 键 词：骨关节植入物 骨关节与生物力学 肋骨骨折 内固定 髓内钉 聚左旋乳酸 镁合金 生物力学 省级基金 

分 类 号：R318[医药卫生—生物医学工程]