Thioperamide treats neonatal hypoxic-ischemic encephalopathy by postsynaptic H1 receptors  

作　　者：Feiyong Jia Lin Du Yunpeng Hao Shicheng Liu Ning Li Huiyi Jiang 

机构地区：[1]Division of Pediatric Neurorehabilitation, Department of Pediatrics, Second Part of First Hospital of Jilin University

出　　处：《Neural Regeneration Research》2013年第19期1814-1822,共9页中国神经再生研究（英文版）

基　　金：supported by Jilin Provincial Science and Technology Department Foundation ofChina, No. 200905134

摘　　要：Thioperamide, a selective histamine H3 receptor antagonist, can increase histamine content in the brain, improve brain edema, and exert a neuroprotective effect. This study aimed to examine the mechanism of action of thioperamide during brain edema in a rat model of neonatal hypoxic ischemic encephalopathy. Our results showed that thioperamide significantly decreased brain water content and malondialdehyde levels, while significantly increased histamine levels and superoxide dismutase activity in the hippocampus. This evidence demonstrates that thioperamide could pre vent oxidative damage and attenuate brain edema following neonatal hypoxicischemic encepha Iopathy. We further observed that changes in the above indexes occurred after combined treatment of thioperamide with the H1 receptor antagonist, pyrilamine, and the H2 receptor antagonist, ci metidine. Experimental findings indicated that pyrilamine reversed the effects of thioperamide; however, cimetidine had no significant influence on the effects of thioperamide. Our present findings suggest that thioperamide can increase brain histamine content and attenuate brain edema and oxidative damage by acting in combination with postsynaptic H1 receptors in a rat model of neo natal hypoxicischemic encephalopathy.Thioperamide, a selective histamine H3 receptor antagonist, can increase histamine content in the brain, improve brain edema, and exert a neuroprotective effect. This study aimed to examine the mechanism of action of thioperamide during brain edema in a rat model of neonatal hypoxic ischemic encephalopathy. Our results showed that thioperamide significantly decreased brain water content and malondialdehyde levels, while significantly increased histamine levels and superoxide dismutase activity in the hippocampus. This evidence demonstrates that thioperamide could pre vent oxidative damage and attenuate brain edema following neonatal hypoxicischemic encepha Iopathy. We further observed that changes in the above indexes occurred after combined treatment of thioperamide with the H1 receptor antagonist, pyrilamine, and the H2 receptor antagonist, ci metidine. Experimental findings indicated that pyrilamine reversed the effects of thioperamide; however, cimetidine had no significant influence on the effects of thioperamide. Our present findings suggest that thioperamide can increase brain histamine content and attenuate brain edema and oxidative damage by acting in combination with postsynaptic H1 receptors in a rat model of neo natal hypoxicischemic encephalopathy.

关 键 词：neural regeneration THIOPERAMIDE histamine histamine receptor antagonist CIMETIDINE pyrilamineneonatal hypoxic-ischemic encephalopathy brain edema hippocampus malondialdehyde super-oxide dismutase grants-supported paper neuroregeneration 

分 类 号：R722.1[医药卫生—儿科]