脂蛋白相关磷脂酶A2活性水平的性别差异及其与心血管病危险因素的关系  

Impact of gender on lipoprotein-associated phospholipase A2 activity and association with known cardiovascular risk factors

作　　者：贾张蓉 赵冬[1] 齐玥[1] 王薇[1] 王淼[1] 孙佳艺[1] 秦兰萍[1] 刘静[1] 

机构地区：[1]首都医科大学附属北京安贞医院北京市心肺血管疾病研究所流行病研究室,100029

出　　处：《中华心血管病杂志》2013年第11期962-967,共6页Chinese Journal of Cardiology

基　　金：国家自然科学基金（81070226）

摘　　要：目的 探讨脂蛋白相关磷脂酶A2（Lp-PLA2）活性水平的性别差异及其与心血管病危险因素的关系.方法 以参加“中国多省市心血管病危险因素队列研究”2002年危险因素调查的1541例北京地区45 ～ 74岁队列人群中资料完整的1471人（男性688人,女性783人）作为研究对象.Lp-PLA2活性水平采用比色法进行检测.对男女两性的Lp-PLA2活性水平以及Lp-PLA2活性与危险因素的关系进行了分析.结果 （1）男女两性Lp-PLA2活性水平分别为（22.73±8.52） nmol·min-1 ·ml-1和（20.01±8.06） nmol·min-1·ml-（P＜0.01）.（2）男性的年龄、腰围、收缩压、舒张压以及高血压患病率高于女性,女性的总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）高于男性（P＜0.05或P＜0.01）.（3）Pearson相关分析显示,男性Lp-PLA2活性水平与肥胖指标（腰围和体质指数）、血压（收缩压和舒张压）、血脂（TC、LDL-C、HDL-C和甘油三酯）均相关（P均＜0.01）;女性Lp-PLA2活性水平与年龄和血脂相关（P＜0.05或P＜0.01）,而与肥胖指标和血压的相关性低于男性（女性r值0.02～0.08;男性r值0.10～0.16）.多因素logistic回归分析调整年龄、腰围、收缩压、空腹血糖、LDL-C、HDL-C、甘油三酯和高敏C反应蛋白后,男性Lp-PLA2活性水平仍高于女性（OR=1.72,95％CI：1.34 ～2.21,P＜0.01）.结论 男性的Lp-PLA2活性水平高于女性,且与主要心血管病危险因素的关系较强,但此性别差异并不能够完全由主要危险因素解释.Objective To explore the impact of gender on lipoprotein-associated phospholipase A2 （Lp-PLA2 ） activity and association with known cardiovascular risk factors. Methods Participants in this study were recruited from Beijing sub-cohort from the Chinese Multi-provincial Cohort Study （CMCS） database. A total of 1471 participants with eomplete laboratory data were included in the study （688 male）. Lp-PLA2 activity was determined by colorimetric assay kit. Lp-PLA2 activity level and correlation between Lp-PLA2 activity and known risk factors were compared between men and women. Results （ 1 ） Lp-PLA2 activity was higher in males than in females [ （22. 73± 8. 52） nmol · min-1· m1-1 vs. （20. 01± 8.06） nmol ~ rain-l · ml-1, P 〈 0.01 ]. （2） Age, waist circumference, systolic blood pressure, diastolic blood pressure and the prevalence of hypertension were higher in males than in females, while total cholesterol, low-density lipoprotein cholesterol （LDL-C） and high-density lipoprotein cholesterol （HDL-C） were higher in females than in males（ P 〈 0. 05 or P 〈 0. 01 ）. （3）Pearson correlation showed that Lp-PLA2 activity was correlated with lipids （ total cholesterol, LDL-C, HDL-C, and triglyceride）, blood pressure （ systolic blood pressure and diastolic blood pressure）, and adiposity associated parameters （waist circumference and body mass index） in males（ all P 〈 0. 01 ） and was correlated with lipid level （total cholesterol, LDL-C, HDL-C, and triglyeeride） and age in females （ P 〈 0. 05 or P 〈 0. 01 ）. Correlations with variables associated with obesity or blood pressure in females were much weaker than those in males （ in females, r = 0. 02 - 0.08 ; in males, r = 0. 10 - 0. 16 ） . （4） After adjustment for age, waist circumference, systolic blood pressure,glucose, LDL-C, HDL-C, triglyceride and high sensitivity C-reactive protein by multiple logistic regression model, Lp-PLA2 activity was still significantly higher in males than in f

关 键 词：心血管疾病 危险因素 性别因素 脂酶A 

分 类 号：R54[医药卫生—心血管疾病]