肾移植受者神经精神损害影响因素分析  

Analysis on lnfluential Factors of Neuropsychic Damages in Renal Transplant Recipients

作　　者：胡智伟 胡岗 蒋慧芳 李唯佳 汪亚群 

机构地区：[1]浙江省第二中医院神经科,杭州310012

出　　处：《医学新知》2000年第4期189-191,共3页New Medicine

摘　　要：为探讨肾移植受者 (RTR)神经精神损害 (NPD)的影响因素及其发病机制 ,对 2 0 5例 RTR的临床资料进行回顾性分析。结果显示本组病例的 NPD发生率为 38% ,类型包括 :脑脓肿、昏迷、颅神经损害、抽动、肌无力、脊神经损害、神经衰弱症状群、精神症状和震颤。排斥反应、高血压、肝损害、医院感染环孢素 A(Cs A)中毒和应用大剂量甲基泼尼松为本组 NPD的主要影响因素 (P <0 .0 1) ;高脂血症、高尿酸血症、高血糖、贫血、红细胞增多症和电解质紊乱也是 NPD的影响因素。结果表明 RTR的 NPD发生率较高 ,与其它系统并发症和某些药物密切相关。应重视RTR其它系统并发症的防治和强调合理用药 ,以切实减少 NPD的发生。To investigate the influential factors and pathogenesis of neuropsychic damages (NPD) in renal trans plant recipients (RTR) preliminarily.The chinical data of 205 cases with RTR were analyzed retrospectively.Results showed that the incidence of NPD in this group was 38 percent.The types of NPD included brain abscess,coma,cranial nerve damage,tic,myasthenia,spinal nerve damage,neurasthenia,mental symptoms and tremor.The main influential factors of NPD in this group were those of rejection, hypertension,hepatic damage,nosocomial infection, cyclosporin A poisoning and high dosage methylprednisolone(P<0.01).The influential factors were also involved in hyperlipemia,hyperuricemia,hyperglycemia,anemia,erythrocytosis and electrolytic disorder.The results indicated that the incidence of NPD in RTR was high, and both closely related to other system complications and some drugs to be used. In order to reduce the incidense of NPD effectively, we should attach the importance to preventing or treating of other system complications and stress the use of drugs rationaliy.

关 键 词：肾移植 受者 神经精神并发症 影响因素 

分 类 号：R699[医药卫生—泌尿科学]