布地奈德联合孟鲁司特对小儿咳嗽变异性哮喘血清白介素-8、肿瘤坏死因子-α及转化生长因子β_1水平的影响  

Influence of Budesonide combining with Montelukast on levels of interleukin-8, tumor necrosis factor-α, and transforming growth factor-β_1 in child cough variant asthma

作　　者：秦蔚[1] 赵宇华[1] 

机构地区：[1]同济大学附属东方医院儿科,上海200120

出　　处：《中国医药导报》2013年第35期95-97,101,共4页China Medical Herald

摘　　要：目的 评估布地奈德联合孟鲁司特对小儿咳嗽变异性哮喘（CVA）患者肺功能及血清炎症因子白介素-8（IL-8）、肿瘤坏死因子-α （TNF-α）及转化生长因子β1（TGF-β1）水平的影响.方法 选择2009年4月～2010年12月在同济大学附属东方医院确诊为CVA的患者62例,将其分为治疗组（31例）和对照组（31例）,对照组予以化痰、抗感染、对症等治疗,治疗组在对照组基础上加用布地奈德雾化吸入（0～5岁,0.5 mL/次;＞5～8岁,1.0 mL/次;＞8岁,1.5 mL/次）,2次/d;孟鲁司特钠每次4 mg,每晚睡前1次,两组治疗时间均为4周.治疗前后测血清IL-8、TNF-α及TGF-β1水平.结果 与治疗前比较,治疗组治疗后血清TGF-β1水平明显升高[（74.56±19.45）ng/L比（35.45±12.42）ng/L,P＜0.01],IL-8[（61.75±23.19）ng/比（107.45±54.25）ng/L]及TNF-α[（13.27±9.42）ng/L比（23.34±11.21）ng/L]水平明显降低（P＜ 0.01）;与对照组治疗后比较,治疗组血清IL-8及TNF-α水平均明显下降,血清TGF-β1水平明显上升（P＜0.01）.结论 布地奈德联合孟鲁司特治疗小儿CVA具有较好的临床效果,能显著改善患者气道炎症反应.Objective To evaluate the influences of Budesonide combining with Montelukast on pulmonary function and levels of interleukin-8 （IL-8）,tumor necrosis factor-α （TNF-α）,and transforming growth factor-β1 （TGF-β1） in child cough variant asthma （CVA）.Methods 62 children patients with definite diagnosis of CVA in Dongfang Hospital Affiliated to Tongji University from April 2009 to December 2010 were selected and evenly divided into treatment group and control group.In the control group,patients were treated by dissolving phlegm,anti-infection,and symptoms.In the treatment group,on the basis of control group,aerosol inhalation of Budesonide twice a day （0-5 years old,0.5 mL once; 〉5-8 years old,1.0 mL once; 〉8years old,1.5 mL once） and 4 mg Montelukast each time and once before sleep at night were added.The course of treatment in both groups was 4 weeks.The levels of IL-8,TNF-α and TGF-β1 were tested before and after treatment.Results Compared with prior treatment,the level of TGF-β1 of post treatment in the treatment group remarkably increased [（74.56±19.45） ng/L vs （35.45±12.42） ng/L,P 〈 0.01] and IL-8 [（61.75±23.19） ng/L vs （107.45±54.25） ng/L] and TNF-α [（13.27±9.42） ng/L vs （23.34±11.21） ng/L] greatly reduced （P 〈 0.01）.In comparison with the control group after treatment,the levels of IL-8 and TNF-α in treatment group obviously decreased,but the level of TGF-β1 greatly increased （P 〈 0.01）.Conclusion Budesonide combining with Montelukast can obtain a good clinical effect on treating child CVA and improve airway inflammation. Keywords：

关 键 词：布地奈德 孟鲁司特 咳嗽变异性哮喘 肺功能 IL-8 TNF-α TGF-β1 

分 类 号：R562.25[医药卫生—呼吸系统]