支气管哮喘冷热哮证受体功能、血栓素A_2-前列腺环素平衡系统关系的临床研究  

Clinical Research on the Relationship Between Receptor′s Function & TXA_2-PGI_2 Equilibrium System in Bronchial Asthma of Cold & Heat Types

作　　者：李植延[1] 甘慧娟[1] 

机构地区：[1]福建中医学院中医系,福建福州350003

出　　处：《福建中医学院学报》2000年第4期1-4,共4页Journal of Fujian College of Traditional Chinese Medicine

基　　金：福建省自然科学基金资助项目!( C96 0 48)

摘　　要：对 63例哮喘发作期患者及 30例正常人的受体功能、TXA2 - PGI2 平衡系统进行测定 ,并与 30例正常人比较 ,结果表明 :支气管哮喘发作期患者血 c AMP及 c AMP/ c GMP均显著降低 ,血c GMP含量明显升高 ,但冷、热哮证之间比较无显著差异 ,哮喘发作期血浆 TXB2 、TXB2 / 6- Keto-PGF1α显著上升 ,而 6- Keto- PGF1α显著降低 ,且 TXB2 水平冷哮证低于热哮证。提示血 TXB2 可作为冷、热哮证不同病理、生理变化的客观指标之一。The receptor′s function and TXA\-2 PGI\-2 equilibrium system have been measured in 63 cases of asthma in attack stage,and 30 normal subjects as controls.The result showed that:in attack stage of bronchial asthma,both cAMP and cAMP/cGMP decreased obviously while cGMP increased,and there was no obvious difference between bronchial asthma of cold and heat types;both TXB\-2 and TXB\-2/6 Keto PGF\-\{1α\} increased obviously while 6 Keto PGF\-\{1α\} decreased,and TXB\-2 in cold type is lower than that in heat type.It indicates that blood TXB\-2 is one of the objective indexes for differenciating the physiological & pathological changes in asthma of cold and heat types.\;

关 键 词：哮喘 诊断 辩证分型 血栓素A2 前列腺环素 

分 类 号：R259.622[医药卫生—中西医结合]