血浆高半胱氨酸的水平及与冠心病患者血脂、颈动脉粥样硬化程度的关系  

Relationship Among Level of Plasma Homocysteine, Blood lipid & Degree of Carotid Atherosclerosis in CHD

作　　者：林一萍[1] 李永鉴[1] 陈玲[1] 陈比特[1] 陈炳旺[1] 游景成[1] 吴瑞荣[1] 柯丹如[2] 

机构地区：[1]福建省中医药研究院,福建福州350003 [2]福建医科大学临床药理研究所,福建福州350004

出　　处：《福建中医学院学报》2000年第4期8-11,共4页Journal of Fujian College of Traditional Chinese Medicine

基　　金：福建省自然科学基金资助项目!( C970 47)

摘　　要：采用巯基 -特异性荧光试剂标记血浆巯基化合物 ,再用 HPLC荧光检测血浆总高半胱氨酸 ( t Hcy)含量 ,测定了 30例正常人和 4 2例冠心病 ( CHD)患者 (其中 2 1例经颈动脉超声检查有不同程度颈动脉斑块及供血不足 )血浆总高半胱氨酸 ( t Hcy)的变化。结果显示 :CHD组 t Hcy的水平明显高于对照组 ( P<0 .0 0 1) ,但与 TG、TC水平均无显著性相关性 ( P>0 .0 5)。而血浆 t Hcy水平与颈动脉斑块积分之间有显著的正相关性。说明体内高半胱氨酸水平增高是引起动脉粥样硬化的一种独立危险因子。测定血浆 t Hcy对心血管病的诊断、预防和治疗具有重要的意义。The changes of the total plasma homocysteine in 42 cases of coronary heart disease(CHD)(of these,21 cases presented different degree of carotid plaques and insufficient blood supply by ultrasonic examination)have been tested,with 30 normal subjects as controls.Methods:plasma mercapto compounds were marked by the fluorescent reagent being characteristics of mercapto,and the contents of total plasma homocysteine were tested by the HPLC fluorescence method.The result showed that the level of tHcy in CHD group was obviously higher than that in the control group (P<0.001),without significant correlation to the level of TG and TC(P>0.05),while with significant positive correlation to the scores of total carotid plaques.It indicates that the increase of in vivo plasma homocysteine is one of the solitary risk factors for atherosclerosis,so that the examination of plasma tHcy is significant to the diagnosis,prevention and treatment for the patient with heart and arteries diseases.\;

关 键 词：高半胱氨酸 动脉粥样硬化 诊断 颈动脉 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]